How gut microbes talk to organs: The role of endocrine and nervous routes.
How gut microbes talk to organs: The role of endocrine and nervous routes.
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DOI：
10.1016/j.molmet.2016.05.011
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发表时间：
2016-09
影响因子：
8.1
通讯作者：
Knauf C
中科院分区：
文献类型：
--
作者：
Cani PD;Knauf C
肠道微生物区系组成和活性的变化与不同的代谢紊乱有关，包括肥胖、糖尿病和心脏代谢紊乱。最近的证据表明，不同的器官直接受到细菌代谢物的影响，这些代谢物可能直接或间接地调节生理和病理过程。我们回顾了肠道微生物通过控制内分泌、肠道和中枢神经系统等不同代谢途径来影响能量、葡萄糖和脂肪稳态的研究进展。这些对话在肥胖和糖尿病的背景下讨论，但也在大脑病理和神经退行性疾病的背景下讨论。肠道微生物区系研究的最新进展，以及与宿主细胞相互作用的特定代谢物的发现，导致了代谢紊乱期间新的器官间通讯的识别。这表明肠道微生物可能被视为未来的“新”治疗伙伴。这篇文章是关于微生物区系的特刊的一部分。
Changes in gut microbiota composition and activity have been associated with different metabolic disorders, including obesity, diabetes, and cardiometabolic disorders. Recent evidence suggests that different organs are directly under the influence of bacterial metabolites that may directly or indirectly regulate physiological and pathological processes. We reviewed seminal as well as recent papers showing that gut microbes influence energy, glucose and lipid homeostasis by controlling different metabolic routes such as endocrine, enteric and central nervous system. These dialogues are discussed in the context of obesity and diabetes but also for brain pathologies and neurodegenerative disorders. The recent advances in gut microbiota investigation as well as the discovery of specific metabolites interacting with host cells has led to the identification of novel inter-organ communication during metabolic disturbances. This suggests that gut microbes may be viewed as “novel” future therapeutic partners. This article is part of a special issue on microbiota.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
64.8
作者：
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影响因子：
4.8
作者：
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通讯作者：
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作者：
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Delzenne NM
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影响因子：
2.4
作者：
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通讯作者：
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