A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea
A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea
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茅苍术根茎中新的倍半萜苷
DOI：
10.1016/s1674-6384(15)60066-1
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发表时间：
2015-11-01
影响因子：
3.8
通讯作者：
Feng, Xu
中科院分区：
文献类型：
--
作者：
Yin, Min;Xiao, Chao-cheng;Feng, Xu
目的研究茅苍术根茎的水溶性化学成分。方法采用柱层析法分离纯化两个倍半萜苷类化合物，并通过波谱分析确定其结构。还通过测定对RAW 264.7细胞系中LPS诱导的NO和PGE（2）生成的抑制活性来评价它们的抗炎活性。结果化合物1为一个新的倍半萜苷，命名为（1 S，4S，5 R，7 R，10 S）-4，11，14-三羟基愈创木-3-酮-11-O-β-D-吡喃葡萄糖苷。化合物2为甘草苷A，活性较弱。结论愈创木酚型糖苷C-10位羟基可能是其抗炎活性的重要部位。
Objective To study the water-soluble chemical constituents from the rhizomes of Atratylodes lancea. Methods Two sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE(2) generation in RAW 264.7 cell lines. Results Compound 1 was a new sesquiterpenoid glycoside, named as (1S,4S,5R, 7R,10S)-4,11,14-trihydroxyguai-3-one-11-O-beta-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity. Conclusion The hydroxyl group at C-10 of guaiol-type glycoside could be important for anti-inflammatory activity.