Effect of screening mammography on cumulative survival of Japanese women aged 40-69 years with breast cancer
Effect of screening mammography on cumulative survival of Japanese women aged 40-69 years with breast cancer
复制标题
乳房X线筛查对日本40-69岁乳腺癌女性累积生存率的影响
DOI：
10.1007/s12282-012-0434-2
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发表时间：
2012
期刊：
影响因子：
4
通讯作者：
Kawai M. Suzuki A. Nishino Y. Ohnuki K. Ishida T. Amari M. Shibuya D. Ohuchi N.
中科院分区：
文献类型：
--
作者：
Kaori Arai;Yui Nakagawa;Toyoto Iwata;Hyogo Horiguchi;Katsuyuki Murata;Kawai M. Suzuki A. Nishino Y. Ohnuki K. Ishida T. Amari M. Shibuya D. Ohuchi N.
背景西方国家的研究主要证明筛查乳房X光检查(MMG)的有效性。本研究旨在评估40-69岁接受筛查和间歇期乳腺癌的日本妇女的累积生存率和死亡风险，将其分为三组：MMG和临床乳房检查(CBE)、单独CBE和自我检查。方法将1995年4月1日至2002年12月31日参加宫城癌症协会筛查项目的126,537名妇女(358,242人筛查)与宫城县癌症登记中心匹配，纳入429例MMG和CBE，522例CBE和3,047例自我检测病例。进行了跟踪，直到死亡之日或2007年12月31日。生存估计采用Kaplan-Meier法。用Cox比例风险模型估计乳腺癌死亡的危险比(HR)和95%可信区间(CI)。结果MMG合并CBE、CBE和自我检测组的女性5年生存率分别为96.8、92.7和86.6%。乳腺癌死亡的危险比(95%CI)分别为2.38(0.72~7.94)和4.44(1.42~13.89)；50~69岁女性乳腺癌死亡比为3.00(1.63~5.50)和4.51(2.69~7.56)。对于40-69岁的日本女性来说，MMG合并CBE可能比单独使用MMG或自我检测更有效。
BackgroundThe effectiveness of screening mammography (MMG) has mainly been demonstrated by studies in western countries. This study was conducted to evaluate cumulative survival and the risk of breast cancer death among Japanese women aged 40–69 years with screening-detected and interval breast cancer divided into three groups: MMG with clinical breast examination (CBE), CBE alone, and self-detection.MethodsBy matching a list of 126,537 women (358,242 person-screenings) who participated in the Miyagi Cancer Society Screening program between 1 April 1995 and 31 December 2002 with the Miyagi Prefectural Cancer Registry, 429 MMG with CBE, 522 CBE, and 3,047 self-detected cases were included in this study. Follow-up was performed until the date of death or 31 December 2007. Survival was estimated by the Kaplan–Meier method. The Cox proportional hazards model was used to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for breast cancer death.ResultsFive-year survival for women in the MMG with CBE, CBE, and self-detection groups was 96.8, 92.7, and 86.6 %, respectively. The HR (95 % CI) for breast cancer death was 2.38 (0.72–7.94) among CBE-screened and 4.44 (1.42–13.89) among self-detected cases for women aged 40–49 years, but was 3.00 (1.63–5.50) among CBE-screened and 4.51 (2.69–7.56) among self-detected cases for women aged 50–69 years relative to cases screened by use of MMG with CBE.ConclusionsIn terms of the survival and risk of breast cancer death, MMG with CBE may be more effective than MMG alone or self-detection for Japanese women aged 40–69 years.