Pregnancy in Renal Transplant Recipients: A UK National Cohort Study
Pregnancy in Renal Transplant Recipients: A UK National Cohort Study
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DOI：
10.2215/cjn.06170612
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发表时间：
2013-02-01
影响因子：
9.8
通讯作者：
Knight, Marian
中科院分区：
文献类型：
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作者：
Bramham, Kate;Nelson-Piercy, Cathy;Knight, Marian
背景和目的大多数关于肾移植妇女妊娠结局的报道都是单中心的、回顾性的，并且与对照组比较的数据较少。本研究的目的是收集英国所有肾移植受者妊娠结局的信息，并将这些数据与同期对照组进行比较。设计、环境、参与者和测量：2007年1月1日至2009年12月31日，通过英国产科监测系统（UKOSS）确定肾移植孕妇。比较队列的数据是从联合国支助处数据库获得的，其中载有在以前的研究中确定的比较妇女的资料。结果也与国家数据进行了比较。结果101例受助人中有105例妊娠。中位妊娠前肌酐为118 μ mol/L。子痫前期的发生率为24%，而对照组为4%。分娩时的中位妊娠期为36周，52%的妇女在妊娠中期（P=0.002）和妊娠晚期（P=0.05）以125 μ mol/L的速度分娩（P=0.001），舒张压>为90 mmHg。结论：在英国，大多数接受肾移植的妇女妊娠是成功的，但产妇和新生儿并发症的发生率仍然很高。中国临床医学杂志，2013,31(2):393 - 398。doi: 10.2215 / CJN.06170612
Background and objectives Most reports of pregnancy outcome in women with kidney transplants are single-center, retrospective, and include small numbers and few are compared with controls. The aim of this study was to collect information about pregnancy outcomes among all kidney transplant recipients in the United Kingdom, managed with current antenatal and nephrologic care, and to compare these data with a contemporaneous control group.Design, setting, participants, & measurements Pregnant women with a kidney transplant were identified through the UK Obstetric Surveillance System (UKOSS) between January 1, 2007 and December 31, 2009. Data on a comparison cohort were obtained from the UKOSS database, containing information on comparison women identified in previous studies. Outcomes were also compared with national data.Results There were 105 pregnancies identified in 101 recipients. Median prepregnancy creatinine was 118 mu mol/L. Preeclampsia developed in 24% compared with 4% of the comparison group. Median gestation at delivery was 36 weeks, with 52% of women delivering at 125 mu mol/L (P=0.001), and diastolic BP >90 mmHg in the second (P=0.002) and third trimesters (P=0.05).Conclusions Most pregnancies in the United Kingdom in women with kidney transplants are successful but rates of maternal and neonatal complications remain high. Clin J Am Soc Nephrol 8: 290-298, 2013. doi: 10.2215/CJN.06170612