Plasmatic lipid profile indicators related to insulin resistance
Plasmatic lipid profile indicators related to insulin resistance
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DOI：
10.1590/s0104-42302009000300030
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Oliveira, Dirce Ribeiro de
中科院分区：
文献类型：
--
作者：
Vasques, Ana Carolina Junqueira;Rosado, Lina Enriqueta Frandsen Paez de Lima;Oliveira, Dirce Ribeiro de
与胰岛素抵抗相关的PLASMATIC LIPID PROFILE指标采用HOMA-IR指数（Homeostasis Model Assessment-Insulin Resistance，稳态模型胰岛素抵抗指数）评价血脂谱生化指标对胰岛素抵抗（Insulin Resistance，IR）的诊断价值。对138名健康男性（20-59岁）进行了评估。分析的血脂生化指标如下：甘油三酯（TG）、总胆固醇（TC）、HDL-C、LDL-C、TC/HDL-C和TG/HDL-C比值。以第75百分位数为IR的截断点，采用斯皮尔曼相关系数、ROC曲线和曲线下面积（AUC）进行统计学分析。TG/HDL-C比值相关性最强，AUC最大（r = 0.334和AUC = 0.724 +/- 0.046，p < 0.001），其次是HDL-C（r = -0.313和AUC = 0.716 +/- 0.052，p < 0.01），TG（r = 0.261和AUC = 0.048 +/- 0.674，p < 0.01）和CT/HDL-C比率（r = 0.259和AUC = 0.655 +/- 0.05，p < 0.01）。TC和LDL-C结果无统计学意义（p > 0.05）。TG/HDL-C比值对IR的鉴别能力最强，是临床上评价IR的一种简便易行的方法，可为成年男性人群提供疾病预防的依据。[Rev阿斯匹灵医学布拉斯2009; 55（3）：342-6]
PLASMATIC LIPID PRO FILE INDICATORS RELATED TO INSULIN RESISTANCEPURPOSE. To investigate the effectiveness of biochemical indicators from the plasmatic lipid profile to identify the insulin resistance (IR), assessed by the HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance).METHODS. 138 healthy men (20-59 years) were evaluated. The lipid profile biochemical indicators analyzed were the following: triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, and TC/HDL-C and TG/HDL-C ratios. The percentile 75 was considered as the cut-off point for IR. Statistical analysis consisted of Spearman correlation coefficient, ROC curves and calculation of the areas under the curve (AUC).RESULT. the TG/HDL-C ratio showed the strongest correlation and the greatest AUC (r = 0.334 and AUC = 0.724 +/- 0.046, p < 0.001) respectively, followed by the HDL-C (r = -0.313 and AUC = 0.716 +/- 0.052, p < 0.01), the TG (r = 0.261 and AUC = 0.048 +/- 0.674, p < 0.01) and CT/HDL-C ratio (r = 0.259 and AUC = 0.655 +/- 0.05, p < 0.01). Results for TC and LDL-C showed no statistical significant (p > 0.05).CONCLUSION. the TG/HDL-C ratio showed the greatest ability to identify IR, proved to be an alternative and easy access instrument to assess IR in clinical practice, therefore providing diseases prevention for the adult male population. [Rev Assoc Med Bras 2009; 55(3): 342-6]