Regional variations of vertebral trabecular bone microstructure with age and gender
Regional variations of vertebral trabecular bone microstructure with age and gender
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DOI：
10.1007/s00198-008-0593-3
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发表时间：
2008-10-01
影响因子：
4
通讯作者：
Bunai, Y.
中科院分区：
文献类型：
--
作者：
Chen, H.;Shoumura, S.;Bunai, Y.
椎体松质骨具有复杂的三维(3D)微结构，具有不均匀的形态。深入了解椎体微观结构特性的区域差异对于评估与年龄和性别相关的椎体骨丢失至关重要，有助于我们更深入地了解椎体骨质疏松的发生机制和相关的骨折风险。本研究的目的是利用显微计算机断层扫描(Micro-CT)和扫描电子显微镜(SEM)来确定椎体松质骨三维微结构随年龄和性别的区域性差异。受试者的年龄和性别分布是均匀的。女性和男性都被分为三个年龄组，62岁、77岁和92岁。在矢状面上，从前上、前下、中、后上、后下各部位制备5个立方体标本。结果骨体积(Bv/Tv)、骨小梁数目(Tb.N)和连接密度(Conn)明显减少。D)，结构模型指数(SMI)在62~77岁和77~92岁之间增加。77岁组男性Tb.N高于女性，Conn高于女性。D在62岁和77岁组。中央和前上区的BV/TV和CON较低。D大于其对应的后下方区域。随着年龄的增长，椎体骨小梁吸收面增多，骨小梁穿孔或断续，骨痂形成增多。BV/TV和CONN下降。D随年龄的变化在女性和男性中相似。在一些微观结构参数上观察到男女之间的显著差异。与年龄相关的椎体松质骨丢失可能是由于吸收活动增加所致。这些发现说明了脊椎骨折的潜在机制。
The vertebral trabecular bone has a complex three-dimensional (3D) microstructure, with inhomogeneous morphology. A thorough understanding of regional variations in the microstructural properties is crucial for evaluating age- and gender-related bone loss of the vertebra, and may help us to gain more insight into the mechanism of the occurrence of vertebral osteoporosis and the related fracture risks.Introduction The aim of this study was to identify regional differences in 3D microstructure of vertebral trabecular bone with age and gender, using micro-computed tomography (micro-CT) and scanning electron microscopy (SEM).Methods We used 56 fourth lumbar vertebral bodies from 28 women and men (57-98 years of age) cadaver donors. The subjects were chosen to give an even age and gender distribution. Both women and men were divided into three age groups, 62-, 77- and 92-year-old groups. Five cubic specimens were prepared from anterosuperior, anteroinferior, central, posterosuperior and posteroinferior regions at sagittal section. Bone specimens were examined by using micro-CT and SEM.Results Reduced bone volume (BV/TV), trabecular number (Tb.N) and connectivity density (Conn. D), and increased structure model index (SMI) were found between ages 62 and 77 years, and between ages 77 and 92 years. As compared with women, men had higher Tb.N in the 77-year-old group and higher Conn. D in the 62- and 77-year-old groups. The central and anterosuperior regions had lower BV/TV and Conn. D than their corresponding posteroinferior region. Increased resorbing surfaces, perforated or disconnected trabeculae and microcallus formations were found with age.Conclusion Vertebral trabeculae are microstructurally heterogeneous. Decreases in BV/TV and Conn. D with age are similar in women and men. Significant differences between women and men are observed at some microstructural parameters. Age-related vertebral trabecular bone loss may be caused by increased activity of resorption. These findings illustrate potential mechanisms underlying vertebral fractures.