Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behaviorin C. elegans
Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behaviorin C. elegans
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DOI：
10.7554/elife.21166
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发表时间：
2017-01-24
期刊：
影响因子：
7.7
通讯作者：
Kim, Dennis H.
中科院分区：
文献类型：
--
作者：
Hilbert, Zoe A.;Kim, Dennis H.
动物的行为是由来自内部状态和环境的感觉信息的整合来指导的。秀丽隐杆线虫多种行为的神经内分泌调节受感觉神经元分泌的β 7/TGF-β配体的控制。在这里，我们表明，C。在生殖成熟期，雄性线虫ASJ感觉神经元对中daf-7表现出改变的雄性特异性表达模式，其功能是促进雄性特异性择偶行为。在ASJ神经元对中开关样调节daf-7表达的分子遗传学分析揭示了多个输入-性别、年龄、营养状况和微生物环境-之间的调节层次，这些输入在行为调节中起作用。我们的研究结果表明，在感觉神经元中基因表达的调节可以在广泛的感觉信息的整合中发挥作用，并促进C。优雅
Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-beta ligand that is secreted from sensory neurons. Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans.