Ligandless Copper-Catalyzed Coupling of Heteroaryl Bromides with Gaseous Ammonia
Ligandless Copper-Catalyzed Coupling of Heteroaryl Bromides with Gaseous Ammonia
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DOI：
10.1002/adsc.201201010
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发表时间：
2013-03-01
影响因子：
5.4
通讯作者：
Scalone, Michelangelo
中科院分区：
文献类型：
--
作者：
Fantasia, Serena;Windisch, Johannes;Scalone, Michelangelo
在乙酰丙酮铜（II） [Cu(acac)2]作为催化剂和没有附加配体的情况下，一系列不同的含N和含s的杂环溴化物可以有效地与气态氨偶联。不稳定的氨基噻吩和氨基苯并噻吩可以在原位进一步反应得到功能化衍生物。
A range of different N- and S-containing heterocyclic bromides can be efficiently coupled with gaseous ammonia in the presence of copper(II) acetylacetonate [Cu(acac)2] as catalyst and in the absence of additional ligands. Unstable aminothiophenes and aminobenzothiophenes can be further reacted in situ to afford functionalized derivatives.