Inbred lines of mice derived from long-term growth selected lines:: unique resources for mapping growth genes
Inbred lines of mice derived from long-term growth selected lines:: unique resources for mapping growth genes
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DOI：
10.1007/s00335-001-3018-6
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发表时间：
2001-09-01
期刊：
影响因子：
2.5
通讯作者：
Hill, WG
中科院分区：
文献类型：
--
作者：
B端nger, L;Laidlaw, A;Hill, WG
在世界各地的几个实验室中，已经收集了经过多代选择的高或低生长的小鼠系，并从这些小鼠系中，通过在爱丁堡进行反复的全同胞交配来开发近交系。有7条高选线和4条低选线（每条低选线与其中一条高选线来自同一基数人口），并对每条线的历史进行总结。爱丁堡实验室70日龄雄性体重最重的自交系（77 g）比最轻的自交系（16 g）高4.8倍，比最不极端高的自交系（41 g）高1.9倍。产仔数、食物摄入量和脂肪含量也有很大差异。这些自交系是QTL或基因定位、候选基因鉴定和上位性效应研究的宝贵资源。
Lines of mice selected for many generations for high or low growth in several laboratories around the world have been collected, and from these, inbred lines are being developed by recurrent full-sib mating in Edinburgh. There are seven high selected lines and four low lines (each low line is from the same base population as one of the high lines), and the histories of each are summarized. Mean body weight of males at 70 days of age in the Edinburgh laboratory in the heaviest inbred line (77 g) is 4.8-fold higher than in the lightest line (16 g), and 1.9-fold higher than in the least extreme high line (41 g). Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects.