CD200+ and CD200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages
CD200+ and CD200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages
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DOI：
10.1016/j.jneuroim.2015.03.013
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发表时间：
2015-05-15
影响因子：
3.3
通讯作者：
Ohnishi, Takanori
中科院分区：
文献类型：
--
作者：
Matsumoto, Shirabe;Tanaka, Junya;Ohnishi, Takanori
Two types of macrophages in lesion core of rat stroke model were identified according to NG2 chondroitin sulfate proteoglycan (NG2) and CD200 expression. NG2(+) macrophages were CD200(-), and vice versa. NG2(-) macrophages expressed two splice variants of CD200 that are CD200L and CD200S. CD200(+) macrophages expressed CD8, CD68, CD163, CCL2, inducible nitric oxide synthase, interleukin-1 beta, Toll-like receptor 4 and transforming growth factor beta, whilst NG2(+) cells expressed a costimulatory factor CD86. Both cell types expressed insulin-like growth factor 1 and CD200R. These results demonstrate that the two macrophage types cannot be classified as either M1 or M2. 2015 Elsevier B.V. All rights reserved.
