RECOGNITION OF SELF ANTIGENS BY SKIN-DERIVED T-CELLS WITH INVARIANT GAMMA-DELTA-ANTIGEN RECEPTORS
RECOGNITION OF SELF ANTIGENS BY SKIN-DERIVED T-CELLS WITH INVARIANT GAMMA-DELTA-ANTIGEN RECEPTORS
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DOI：
10.1126/science.1828619
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发表时间：
1991-06-07
期刊：
影响因子：
56.9
通讯作者：
ALLISON, JP
中科院分区：
文献类型：
--
作者：
HAVRAN, WL;CHIEN, YH;ALLISON, JP
Thy-1+树突状表皮T细胞（德克斯）表达不变的γ-δ-抗原受体，并与鼠表皮中的角质形成细胞密切接触，从而提高了角质形成细胞表达这些T细胞抗原受体配体的可能性。 Thy-1+德克斯通过与角质形成细胞的相互作用而被刺激产生淋巴因子。 这种刺激是通过dEC抗原受体介导的，并且似乎不受主要组织相容性复合体的限制。 因此，德克斯可以识别自身抗原，并可能参与细胞损伤的免疫监视，而不是外来抗原。
Thy-1+ dendritic epidermal T cells (dECs) express invariant gamma-delta-antigen receptors and are found in intimate contact with keratinocytes in murine epidermis - thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells. Thy-1+ dECs were stimulated to produce lymphokines by interaction with keratinocytes in vitro. This stimulation was mediated through the dEC antigen receptor and did not appear to be restricted by the major histocompatibility complex. Thus, dECs can recognize self antigens and may participate in immune surveillance for cellular damage rather than for foreign antigens.