Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kB) in the retina
Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kB) in the retina
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DOI：
10.1007/s00592-004-0165-8
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发表时间：
2004-12-01
影响因子：
3.8
通讯作者：
Chen, S
中科院分区：
文献类型：
--
作者：
Kowluru, RA;Chakrabarti, S;Chen, S
高血压是糖尿病视网膜病变发展的主要潜在因素之一。在糖尿病中，视网膜微血管细胞在其他组织病理学变化可检测到之前经历加速的凋亡。我们研究了重新建立良好的代谢控制（GC）对视网膜凋亡执行酶caspase-3和核转录因子NF-κ B激活的影响。在链脲佐菌素糖尿病大鼠中，糖化血红蛋白>11.0%的代谢控制（PC）差2个月或6个月，随后是7个月的GC（糖化血红蛋白
Hyperglycemia is one of the major underlying factors in the development of retinopathy in diabetes. Retinal microvascular cells undergo accelerated apoptosis before other histopathological changes are detectable in diabetes. We examined the effect of re-institution of good metabolic control (GC) on the activation of retinal apoptosis executor enzyme, caspase-3, and nuclear transcriptional factor NF-kB. In streptozotocin diabetic rats, two or six months of poor metabolic control (PC) with glycated hemoglobin >11.0% was followed by seven additional months of GC (glycated hemoglobin