Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
复制标题
DOI：
10.1016/j.bmcl.2008.07.089
复制
发表时间：
2008-11-15
影响因子：
2.7
通讯作者：
Blackwell, Helen E.
中科院分区：
文献类型：
--
作者：
Geske, Grant D.;Mattmann, Margrith E.;Blackwell, Helen E.
A focused library of N-aryl l-homoserine lactones was designed around known lactone leads and evaluated for antagonistic and agonistic activity against quorum-sensing receptors in Agrobacterium tumefaciens, Pseudomonas aeruginosa, and Vibrio fischeri. Several compounds were identified with significantly heightened activities relative to the lead compounds, and new structure-activity relationships (SARs) were delineated. Notably, 4-substituted N-phenoxyacetyl and 3-substituted N-phenylpropionyl l-homoserine lactones were identified as potent antagonists of TraR and LuxR, respectively.
登录
查看更多内容
影响因子：
15
作者：
Geske, Grant D.;O'Neill, Jennifer C.;Blackwell, Helen E.
通讯作者：
Blackwell, Helen E.
影响因子：
4
作者：
Geske, Grant D.;O'Neill, Jennifer C.;Blackwell, Helen E.
通讯作者：
Blackwell, Helen E.
影响因子：
3.6
作者：
Lupp, C;Urbanowski, M;Ruby, EG
通讯作者：
Ruby, EG
影响因子：
3.2
作者：
Geske, Grant D.;ONeill, Jennifer C.;Blackwell, Helen E.
通讯作者：
Blackwell, Helen E.
影响因子：
3.6
作者：
Lee, JH;Lequette, Y;Greenberg, EP
通讯作者：
Greenberg, EP