Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies
Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies
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DOI：
10.1093/ije/dyt002
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发表时间：
2013-04-01
影响因子：
7.7
通讯作者：
Vrijheid, Martine
中科院分区：
文献类型：
--
作者：
Casas, Maribel;Chatzi, Leda;Vrijheid, Martine
背景母亲孕前肥胖可能与婴儿神经心理发育受损有关；然而，很少有研究报道这种联系是否与宫内机制有关。方法我们评估了母亲孕前超重和肥胖是否与两个出生队列中11-22个月儿童的认知和精神运动发育得分(平均100+/-15)有关：环境和儿童(INMA，西班牙；n=1967)和母婴(希腊Rhea：n=412)。结果超重和肥胖母亲的比例，INMA分别为18%和8%，RHEA分别为20%和11%。在调整了社会经济变量和父亲BMI后，母亲孕前肥胖与INMA(减分：-2.72；95%CI：-5.35，-0.10)和RHEA(减分：-3.71；95%CI：-8.45，1.02)中婴儿认知发育评分的下降有关。在两个队列中都有证据表明持续的母亲BMI存在剂量-反应关系。父亲超重/肥胖与婴儿认知发育无关。与精神运动得分的相关性在队列之间并不一致，在RHEA中父亲的BMI比母亲的BMI更强。结论这项研究在两个肥胖患病率中等偏高的出生队列中表明，母亲孕前肥胖与儿童早期认知发展下降有关。这种关联似乎更有可能是母性的，而不是共同的家庭和社会机制，但需要进一步的研究来从其他母性混杂因素中分离出直接的宫内影响。
Background Maternal pre-pregnancy obesity may be associated with impaired infant neuropsychological development; however, there are few studies and it is unclear if reported associations are due to intrauterine mechanisms.Methods We assessed whether maternal pre-pregnancy overweight and obesity were associated with cognitive and psychomotor development scores (mean 100 +/- 15) of children aged 11-22 months in two birth cohorts: Environment and Childhood (INMA, Spain; n = 1967) and Mother-Child (RHEA, Greece: n = 412). Paternal body mass index (BMI) was used as a negative control exposure.Results The percentage of overweight and obese mothers was 18% and 8%, respectively, in INMA and 20% and 11% in RHEA, respectively. Maternal pre-pregnancy obesity was associated with reduced infant cognitive development scores in both INMA (score reduction: -2.72; 95% CI: -5.35, -0.10) and RHEA (score reduction: -3.71; 95% CI: -8.45, 1.02), after adjusting for socioeconomic variables and paternal BMI. There was evidence in both cohorts of a dose-response relationship with continuous maternal BMI. Paternal overweight/obesity was not associated with infant cognitive development. Associations with psychomotor scores were not consistent between cohorts, and were stronger for paternal than maternal BMI in RHEA.Conclusions This study in two birth cohorts with moderately high obesity prevalence suggests that maternal pre-pregnancy obesity is associated with reduced child cognitive development at early ages. This association appears more likely to be due to maternal than shared family and social mechanisms, but further research is needed to disentangle a direct intrauterine effect from other maternal confounding factors.