Red-cell pyrimidine 5'-nucleotidase and lead poisoning.
Red-cell pyrimidine 5'-nucleotidase and lead poisoning.
复制标题
红细胞嘧啶 5-核苷酸酶和铅中毒。
DOI：
10.1016/0009-8981(78)90056-6
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Kaplan
中科院分区：
文献类型：
--
作者：
H. Buc;J. Kaplan
为了确定其作为铅中毒生物学指标的价值，我们对22例不同程度铅中毒的受试者的红细胞嘧啶5‘-核苷酸酶(PY5N)活性以及经典参数进行了研究。在所有病例中，发现红细胞PY5N活性降低，即使其他大多数铅中毒生物测试仍为阴性。低于每百毫升血液含铅150μg的水平，红细胞PY5N下降的幅度与外周血液中的铅水平大致成正比。结论：红细胞PY5N是一种简便、可靠、灵敏的铅暴露指标。
In an effort to determine its value as a biological index of lead poisoning, we investigated the red-cell pyrimidine 5'-nucleotidase (Py5N) activity, along with the classical parameters, in 22 subjects with varying degrees of lead intoxication. In all cases, the red-cell Py5N activity was found to be decreased, even when most of the other biological tests of lead intoxication remained negative. Below the level of 150 μg of lead per 100 ml of blood, the magnitude of the red-cell Py5N decrease was roughly proportional to the level of lead in peripheral blood. We conclude that red-cell Py5N is a convenient, reliable and sensitive index of lead exposure.