AIRWAY SIZE IS RELATED TO SEX BUT NOT LUNG SIZE IN NORMAL ADULTS
AIRWAY SIZE IS RELATED TO SEX BUT NOT LUNG SIZE IN NORMAL ADULTS
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DOI：
10.1152/jappl.1987.63.5.2042
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发表时间：
1987-11-01
影响因子：
3.3
通讯作者：
MEAD, J
中科院分区：
文献类型：
--
作者：
MARTIN, TR;CASTILE, RG;MEAD, J
在个体中，通过总肺活量(TLC)或肺活量(VC)评估的肺大小似乎与通过最大呼气流量(MEF)生理评估的气道大小无关。格林等人。(J.Appl.)物理。37：67-74,1974)创造了失调(不平等生长)一词，以表达实质和呼吸道大小之间的这种明显的个体间差异。我们使用呼吸道大小的生理和解剖指标重新检查了这种差异。对26名男性和28名女性健康不吸烟成人进行了声学反射面积(AAAR)、最大呼气流速(PEFR)、最大呼气流量(MEF)和肺容量的测量。在S的TLC相匹配(5-6.5L)的男性和女性的评估中，性别对大气道大小的这些指标的影响是显著的。在这个亚组中，男性aaar为2.79。+-。0.45 cm~2，雌性为1.99±-。0.67平方厘米(P<；0.01)。男性S在25%VC过期后(MEF25)的PEFR和MEF比这一亚组中的女性高23%(P<；0.05)。对于整个受试组，一旦这些与性别相关的差异被考虑在内，aaar与TLC没有显著的相关性，而PEFR和MEF25充其量与TLC的相关性仍然很弱。我们的结论是，即使在控制了TLC之后，男性的气管面积也明显大于女性，在控制了与性别相关的差异后，成人的沙眼大小与广泛的肺大小无关。
Within individuals, lung size as assessed by total lung capacity (TLC) or vital capacity (VC) appears to be unrelated to airway size as assessed physiologically by maximum expiratory flows (MEF). Green et al. (J. Appl. Physiol. 37: 67-74, 1974) coined the term dysanapsis (unequal growth) to express this apparent interindividual discrepancy between parenchymal and airway size. We have reexamined this discrepancy using both physiological and anatomic indexes of airway size. Airway area by acoustic reflectance (AAAR), peak expiratory flow rates (PEFR), MEF, and lung volumes were measured in 26 male and 28 female healthy nonsmoking adults. The effect of sex on these indexes of large airway size was significant when assessed in a subset of males and females whose TLC''s were matched (5.0-6.5 liters). Within this subset, male AAAR was 2.79 .+-. 0.45 cm2, whereas female AAAR was 1.99 .+-. 0.67 cm2 (P < 0.01). Male''s PEFR and MEF after 25% of VC had been expired (MEF25) were 23% greater than those of fmeales within this subset (P < 0.05). For the entire group of subjects, once these sex-related differences had been accounted for, AAAR was not significantly related to TLC, whereas PEFR and MEF25 remained at best weakly related to TLC. We conclude that tracheal areas in males are significantly larger than those of females even after controlling for TLC and that after controlling for sex-related differences, trachela size in adults is unrelated to lung size across a broad range of lung sizes.