Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction.
Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction.
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DOI：
10.1016/j.stemcr.2017.01.013
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发表时间：
2017-03-14
影响因子：
5.9
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Takano M;Kawabata S;Shibata S;Yasuda A;Nori S;Tsuji O;Nagoshi N;Iwanami A;Ebise H;Horiuchi K;Okano H;Nakamura M
在世界范围内，老年脊髓损伤（SCI）患者的数量正在增加，这对患者和社会都是一个严重的负担。已有研究表明，神经干细胞（NSC）移植是幼龄动物脊髓损伤的有效治疗方法。本研究表明，NSC移植在老年小鼠和年轻小鼠中同样有效，尽管老年小鼠在脊髓损伤后表现出更严重的神经功能缺损。移植到老年小鼠的NSCs比移植到年轻小鼠的NSCs存活率更高。此外，我们发现神经营养因子HGF在老龄脊髓损伤小鼠NSC移植后的功能恢复中发挥了关键作用。本研究的意外结果表明，NSC移植是一种潜在的脊髓损伤治疗方式，即使是在老年患者中。在这篇文章中，Nakamura， Okano及其同事报道，尽管老龄小鼠在脊髓损伤后的损伤更严重，但NSC移植治疗在老龄小鼠和年轻小鼠中同样有效。HGF是在老龄脊髓损伤小鼠中观察到的NSC移植后增强功能恢复的关键因素。
The number of elderly patients with spinal cord injury (SCI) is increasing worldwide, representing a serious burden for both the affected patients and the community. Previous studies have demonstrated that neural stem cell (NSC) transplantation is an effective treatment for SCI in young animals. Here we show that NSC transplantation is as effective in aged mice as it is in young mice, even though aged mice exhibit more severe neurological deficits after SCI. NSCs grafted into aged mice exhibited better survival than those grafted into young mice. Furthermore, we show that the neurotrophic factor HGF plays a key role in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI. The unexpected results of the present study suggest that NSC transplantation is a potential therapeutic modality for SCI, even in elderly patients. Aged mice exhibited more severe neurological deficits after SCI than young mice Grafted NSCs showed better survival in aged mice Aged mice exhibited enhanced functional recovery after NSC transplantation HGF was essential for efficient functional recovery in aged mice with SCI In this article, Nakamura, Okano, and colleagues report that NSC transplantation therapy is as effective in aged mice as it is in young mice, despite the more severe damage after SCI in aged mice. HGF is a key factor in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI.