Usefulness of Isosorbide Dinitrate and Hydralazine as Add-on Therapy in Patients Discharged for Advanced Decompensated Heart Failure
Usefulness of Isosorbide Dinitrate and Hydralazine as Add-on Therapy in Patients Discharged for Advanced Decompensated Heart Failure
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DOI：
10.1016/j.amjcard.2008.12.028
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发表时间：
2009-04-15
影响因子：
2.8
通讯作者：
Sokos, George
中科院分区：
文献类型：
--
作者：
Mullens, Wilfried;Abrahams, Zuheir;Sokos, George
支持口服硝酸异山梨酯和/或肼丙嗪(I/H)作为标准神经激素拮抗剂治疗晚期失代偿性心力衰竭(ADHF)的数据有限，特别是在非非洲裔美国人人群中。我们的目标是确定在出院的ADHF患者中，在标准神经激素阻断的基础上增加I/H是否与改善血流动力学特征和改善临床结果有关。我们回顾了2003-2006年间连续收治的ADHF患者的心脏指数。
Data supporting the use of oral isosorbide dinitrate and/or hydralazine (I/H) as add-on therapy to standard neurohormonal antagonists in advanced decompensated heart failure (ADHF) are limited, especially in the non-African-American population. Our objective was to determine if addition of I/H to standard neurohormonal blockade in patients discharged from the hospital with ADHF is associated with improved hemodynamic profiles and improved clinical outcomes. We reviewed consecutive patients with ADHF admitted from 2003 to 2006 with a cardiac index