ANATOMICAL BASIS OF THE STRAUB PHENOMENON
ANATOMICAL BASIS OF THE STRAUB PHENOMENON
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DOI：
10.1111/j.1476-5381.1960.tb00277.x
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发表时间：
1960-01-01
期刊：
影响因子：
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通讯作者：
GROSSMAN, MH
中科院分区：
文献类型：
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作者：
BILBEY, DLJ;SALEM, H;GROSSMAN, MH
吗啡100毫克/ kg- s.c.在小鼠中产生尾部的刚性，其以S形曲线横跨背部竖立（Straub反应）;还存在兴奋性、四肢伸展、粪便排泄和会阴突出。它被取消了全身麻醉和筒箭毒碱。手术过程表明，这种现象主要是由骶尾骨背肌产生的，腰骶髓及其外周流出应该是完整的，这些单位应该有足够的循环。这与电生理学一致。Leim-dorfer的证据表明，吗啡促进了脊髓-脊髓通路活动的增加。
Morphine 100 mg./kg- s.c. in mice produces a rigidity of the tail which is erected across the back in an S-shaped curve (Straub reaction); there is also excitability, extension of the limbs, voidance of faeces, and prominence of the perineum. It was abolished by general anaesthesia and by tubocurarine. Surgical procedures indicate that the phenomenon is produced mainly by the sacrococcygeus dorsalis muscle and that the lumbosacral cord with its peripheral outflow should be intact and these units should have an adequate circulation. This is in agreement with the electrophysiol. evidence of Leim-dorfer who suggested that morphine facilitated an increased activity in cerebro-spinal pathways.