Simple fabrication of hollow poly-lactic acid microspheres using uniform microbubbles as templates
Simple fabrication of hollow poly-lactic acid microspheres using uniform microbubbles as templates
复制标题
DOI：
10.1016/j.matlet.2008.12.030
复制
发表时间：
2009-03
影响因子：
3
通讯作者：
T. Makuta;S. Takada;H. Daiguji;F. Takemura
中科院分区：
文献类型：
--
作者：
T. Makuta;S. Takada;H. Daiguji;F. Takemura
开发了一种简单的方法，使用微泡作为模板来制造覆盖有可生物降解聚合物的空心微球。通过将直径约2微米的微气泡稳定地保持在溶解生物可降解聚合物的溶剂液滴内，然后缓慢干燥溶剂，获得平均内径约2微米、壳厚度约500纳米的中空微球。这种简单的方法被成功地使用均匀的 2 µm 直径气泡作为模板，轻松制造出覆盖有聚乳酸 (PLA) 的均匀空心微球。
A simple method was developed that uses microbubbles as templates to fabricate hollow microspheres covered with a biodegradable polymer. By stably keeping microbubbles with the diameter of about 2 µm inside a solvent droplet dissolving a biodegradable polymer and then slowly drying the solvent, hollow microspheres that had an average inner diameter of about 2 µm and a shell thickness of about 500 nm were obtained. This simple method was successfully used to easily fabricate uniform hollow microspheres covered with poly-lactic acid (PLA) by using uniform 2-µm-diameter bubbles as templates.