Measurement of bone mineral density via light scattering.
Measurement of bone mineral density via light scattering.
复制标题
通过光散射测量骨矿物质密度。
DOI：
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发表时间：
2004
影响因子：
3.5
通讯作者：
D. Attenburrow
中科院分区：
文献类型：
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作者：
N. Ugryumova;S. Matcher;D. Attenburrow
在这项研究中，我们已经调查了潜在的光学技术监测骨密度（BMD）通过散射系数的变化。对于五个骨样品中的每一个，使用积分球和CCD光谱仪在520-960 nm的波长范围内测量漫反射和透射系数。这些被转换成光学吸收和散射系数，使用蒙特卡罗反演程序。测量样品浸泡在甲酸溶液中不同的时间长度，以研究减少BMD的光学性能的影响。完全脱矿质后，光散射系数下降了4倍。从观察到的测量波动程度，我们估计，BMD可以测量的准确度为7%，如果光散射可以测量的准确度为10%。我们还报告了使用光学相干断层扫描（OCT）的骨散射的初步测量。在有和没有覆盖骨膜的干燥样品上获得了3%的侧间变异性。这些结果表明，用于测量光学散射的微创技术，如OCT，可能在监测BMD的区域变化中发挥作用。这可能是我们理解骨重建及其与骨关节炎关系的一个重要进展。积分球和OCT测量也表明，光在骨中的传输是空间各向异性的。OCT用于评估获得体内结果的概率。
In this study we have investigated the potential of optical techniques to monitor changes in bone mineral density (BMD) via changes in scattering coefficient. For each of five bone samples, diffuse reflection and transmission coefficients were measured over the wavelength range 520-960 nm using an integrating sphere and CCD spectrometer. These were converted into optical absorption and scattering coefficients using a Monte Carlo inversion procedure. Measurements were made on samples immersed in formic acid solution for different lengths of time in order to investigate the effect of reduction in BMD on the optical properties. After full demineralization, the optical scattering coefficient fell by a factor 4. From the observed degree of fluctuation of the measurements, we estimate that BMD could be measured with an accuracy of 7% if optical scattering can be measured with an accuracy of 10%. We also report preliminary measurements of bone scattering using optical coherence tomography (OCT). An inter-side variability of 3% is obtained on dry samples with and without overlying periosteum. These results suggest that minimally invasive techniques for measuring optical scattering, such as OCT, may have a role in monitoring regional changes in BMD. This could be an important advance in our understanding of bone remodelling and its relationship to osteoarthritis. Both the integrating sphere and OCT measurements also suggest that light transport in bone is spatially anisotropic. OCT was used to assess probability of obtaining results in vivo.