Mouse allergen. II. The relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma
Mouse allergen. II. The relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma
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DOI：
10.1067/mai.2000.110795
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发表时间：
2000-12-01
影响因子：
14.2
通讯作者：
Wood, RA
中科院分区：
文献类型：
--
作者：
Phipatanakul, W;Eggleston, PA;Wood, RA
背景资料：虽然小鼠过敏原是导致实验室工作人员职业性哮喘的已知原因，但其在家庭环境中的潜在意义从未被研究过。目的：本研究旨在确定小鼠过敏的患病率及其与小鼠过敏原暴露和疾病活动的关系。来自国家合作城市内哮喘研究的499名受试者的子集具有足够用于小鼠过敏原分析的灰尘样本，以及有效的穿刺皮肤试验（PST）结果，分析数据以将小鼠过敏原暴露和其他风险因素与小鼠致敏和哮喘发病率相关，结果：499名儿童中有89名（18%）的小鼠皮肤试验反应阳性，家中厨房中的小鼠过敏原水平高于中位数（1.60 mug/g）的儿童的小鼠致敏率显著较高（23% vs 11%，P = 0.007）。特应性也与小鼠致敏显着相关，具有4次以上阳性PST反应的人中，有40%对小鼠敏感，而没有其他阳性PST反应的人中，这一比例为4%（P < .0001）。当将特应性和暴露一起考虑时，53%的具有超过4个阳性PST反应和高于中位数的过敏原水平的人对小鼠过敏原具有阳性PST反应，而22%的具有超过4个阳性PST反应和低于中位数的过敏原水平的人具有阳性PST反应（P < .0001）。小鼠过敏原暴露，致敏，哮喘发病率的任何措施之间的关系是没有统计学意义，结论：小鼠过敏原可能是一个重要的室内过敏原在内城儿童哮喘，与暴露和过敏性小鼠致敏。
Background: Although mouse allergen is known to cause occupational asthma in laboratory workers, its potential significance in home environments has never been studied.Objective: This study was designed to define the prevalence of mouse sensitivity and its relationship to mouse allergen exposure and disease activity in inner-city children with asthma,Methods: A subset Of 499 subjects from the National Cooperative Inner-City Asthma Study had dust samples adequate for mouse allergen analysis, as well as valid puncture skin test (PST) results, Data were analyzed to relate mouse allergen exposure and other risk factors to mouse sensitization and asthma morbidity,Results: Eighty-nine (18%) of the 499 children had a positive mouse skin test response, Children whose homes had mouse allergen levels above the median (1.60 mug/g) in the kitchen had a significantly higher rate of mouse sensitization (23% vs 11%, P = .007). Atopy was also significantly related to mouse sensitization, with 40% of those with more than 4 positive PST responses having mouse sensitivity compared with 4% of those with no other positive PST responses (P < .0001). When atopy and exposure were considered together, 53% of those with more than 4 positive PST responses and allergen levels above the median had a positive PST response to mouse allergen compared with 22% of those with more than 4 positive PST responses and allergen levels below the median (P < .0001). The relationship among mouse allergen exposure, sensitization, and any measures of asthma morbidity was not statistically significant,Conclusions: Mouse allergen may be an important indoor allergen in inner-city children with asthma, with exposure and atopy contributing to mouse sensitization.