Titanocene(II)-promoted, one-pot, three-component coupling of thioacetals, alkynyl sulfones, and carbonyl compounds:: Highly stereoselective formation of tert-homopropargyl alcohols
Titanocene(II)-promoted, one-pot, three-component coupling of thioacetals, alkynyl sulfones, and carbonyl compounds:: Highly stereoselective formation of tert-homopropargyl alcohols
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DOI：
10.1021/ol071077w
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发表时间：
2007-07-19
期刊：
影响因子：
5.2
通讯作者：
Tsubouchi, Akira
中科院分区：
文献类型：
--
作者：
Takeda, Takeshi;Ando, Maiko;Tsubouchi, Akira
用Cp2Ti[P(OEt)(3)](2)对硫缩醛进行脱硫钛化制备二茂钛烷基烯配合物，与烷基甲基砜反应生成有机钛，得到对芳酮和α、β不饱和酮具有高非对构选择性的叔同丙炔醇。
Titanocene alkylidene complexes, generated by desulfurizative titanation of thioacetals with Cp2Ti[P(OEt)(3)](2), reacted with alkynyl methyl sulfones to produce organotitanium species, which gave tert-homopropargyl alcohols with high diastereoselectivity on treatment with aromatic and alpha,beta-unsaturated ketones.