The pacemaker current: From basics to the clinics
The pacemaker current: From basics to the clinics
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DOI：
10.1111/j.1540-8167.2006.00736.x
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发表时间：
2007-03-01
影响因子：
2.7
通讯作者：
DiFrancesco, Dario
中科院分区：
文献类型：
--
作者：
Barbuti, Andrea;Baruscotti, Mirko;DiFrancesco, Dario
舒张期起搏器电流的激活是心脏起搏器细胞舒张期去极化和自发活动的主要过程。自主神经递质的i-f调制负责心率的变时性调节。鉴于其在起搏中的作用，I-f一直是临床上旨在开发其心率控制功能的主要研究目标。在这篇简短的综述中，我们描述了基于i-f起搏的概念在临床上的一些最新应用。
Activation of the pacemaker ("funny," I-f) current during diastole is the main process underlying generation of the diastolic depolarization and spontaneous activity of cardiac pacemaker cells. I-f modulation by autonomic transmitters is responsible for the chronotropic regulation of heart rate. Given its role in pacemaking, I-f has been a major target of investigation aimed to exploit its rate-controlling function in a clinical perspective. In this short review, we describe some of the most recent clinically relevant applications of the concept of I-f-based pacemaking.