Skeletal Editing: Interconversion of Arenes and Heteroarenes
Skeletal Editing: Interconversion of Arenes and Heteroarenes
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骨架编辑：芳烃和杂芳烃的相互转换
DOI：
10.1002/hlca.202200182
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发表时间：
2023
影响因子：
1.8
通讯作者：
Joynson B
中科院分区：
文献类型：
--
作者：
Joynson B
骨架编辑包括通过有选择地插入、删除或交换原子来对分子的核心进行特定的点改变。因此，它代表了一种潜在的强大的复杂底物的阶梯经济修饰策略，是对以分子外围为目标的C−H官能化方法的完美补充。鉴于它们在生物活性化合物中的普遍存在，对芳香族杂环进行骨架编辑从而在芳香族杂环之间进行相互转化的能力特别有价值。这篇综述总结了骨架编辑应用于芳环相互转化的最近和关键的历史例子；我们预计它不仅将有助于突出当前骨架编辑方法的创新和使能性质，而且还将突出该领域仍然存在的巨大机会。
Skeletal editing involves making specific point‐changes to the core of a molecule through the selective insertion, deletion or exchange of atoms. It thus represents a potentially powerful strategy for the step‐economic modification of complex substrates and is a perfect complement to methods such as C−H functionalization that target the molecular periphery. Given their ubiquity in biologically active compounds, the ability to perform skeletal editing on – and therefore interconvert between – aromatic heterocycles is especially valuable. This review summarizes both recent and key historical examples of skeletal editing as applied to interconversion of aromatic rings; we anticipate that it will serve to highlight not only the innovative and enabling nature of current skeletal editing methods, but also the tremendous opportunities that still exist in the field.