COMPARISON OF BIOIMPEDANCE SPECTROSCOPY AND MULTIFREQUENCY BIOIMPEDANCE ANALYSIS FOR THE ASSESSMENT OF EXTRACELLULAR AND TOTAL-BODY WATER IN SURGICAL PATIENTS
COMPARISON OF BIOIMPEDANCE SPECTROSCOPY AND MULTIFREQUENCY BIOIMPEDANCE ANALYSIS FOR THE ASSESSMENT OF EXTRACELLULAR AND TOTAL-BODY WATER IN SURGICAL PATIENTS
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DOI：
10.1042/cs0890651
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发表时间：
1995-12-01
期刊：
影响因子：
6
通讯作者：
DEBEAU, A
中科院分区：
文献类型：
--
作者：
HANNAN, WJ;COWEN, SJ;DEBEAU, A
1.细胞外和全身水分的测量提供了关于手术患者营养状况的有用信息，并且可以通过不同频率的全身生物阻抗测量来估计。在50个频率从5 kHz到1 MHz的电阻和电抗测量29名手术患者（17名男性，12名女性），其细胞外液与全身水的比率范围很广。对电抗与电阻数据的频谱的拟合给出了在频率为零和无穷大时的预测电阻。通过这种生物阻抗谱技术测定的细胞外和全身水的值对从放射性同位素稀释获得的值进行回归。估计值的标准误差分别为1.8931和3.2591.阻力指数（高度（2）/阻力）在选定的频率分别在5 kHz和200 kHz的细胞外和全身水的相关性最高，和预测方程从多元逐步回归也表明，这些是最佳的频率。该多频生物阻抗分析方法估计的标准误差分别为1.9371和2.6061。为了评估这两种方法测量细胞外和总体内水分变化的能力，在15名患者的亚组中间隔10分钟重复测量，评估再现性。生物阻抗谱给出的细胞外和全身水的平均变异系数分别为0.9%和3.0%。对于多频生物阻抗分析，相应的变异系数为0.9%和0.6%。它的结论是，一个简单的阻抗分析仪操作在只有两个频率比较有利的更复杂的光谱技术，用于测定细胞外和全身水在手术患者。
1. Measurements of extracellular and total body water provide useful information on the nutritional status of surgical patients and may be estimated from whole-body bio-impedance measurements at different frequencies.2. Resistance and reactance were measured at 50 frequencies from 5 kHz to 1 MHz in 29 surgical patients (17 males, 12 ferhales) with a wide range of extracellular to total body water ratios.3. A fit to the spectrum of reactance versus resistance data gave predicted resistances at frequencies zero and infinity. Values of extracellular and total body water determined by this bio-impedance spectroscopy technique were regressed against values obtained from radioisotope dilution. The standard errors of the estimate were 1.8931 and 3.2591 respectively.4. Resistance indices (height(2)/resistance) at selected frequencies gave the highest correlations with extracellular and total body water at 5 kHz and 200 kHz respectively, and prediction equations derived from multiple stepwise regressions also showed these to be the optimum frequencies. The standard errors of the estimate for this multi-frequency bio-impedance analysis method were 1.9371 and 2.6061 for extracellular and total body water respectively.5. To assess the ability of the two methods to measure changes in extracellular and total, body water, reproducibility was assessed from repeat measurements 10 min apart in a subgroup of 15 patients. Bio-impedance spectroscopy gave mean coefficients of variation for extracellular and total body water of 0.9% and 3.0% respectively. For multifrequency bio-impedance analysis the corresponding coefficients of variation were 0.9% and 0.6%.6. It is concluded that a simple impedance analyser operating at only two frequencies compares favourably with the more complex spectroscopy technique for the determination of extracellular and total body water in surgical patients.