CHOROIDAL THICKNESS, VASCULAR FACTORS, AND AGE-RELATED MACULAR DEGENERATION The ALIENOR Study
CHOROIDAL THICKNESS, VASCULAR FACTORS, AND AGE-RELATED MACULAR DEGENERATION The ALIENOR Study
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DOI：
10.1097/iae.0000000000002237
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发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Delcourt, Cecile
中科院分区：
文献类型：
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作者：
Gattoussi, Sarra;Cougnard-Gregoire, Audrey;Delcourt, Cecile
目的：研究黄斑中心凹下脉络膜厚度与血管危险因素和年龄相关性黄斑变性的关系。方法：Alienor 研究的 261 名参与者对黄斑进行了分级增强深度成像光学相干断层扫描，并获得了有关血管和遗传危险因素（通过面对面访谈和空腹血样评估）和年龄相关性黄斑变性状态（通过视网膜照片和视网膜照片评估）的可用数据。光学相干断层扫描）。在穿过中心凹的一次水平扫描上手动测量中心凹下脉络膜厚度。结果：在多变量混合线性模型中，中心凹下脉络膜厚度与年龄大于 80 岁（-21.77 μm，P = 0.02）、眼轴长度（-21.77 μm，P < 0.0001）、重度吸烟（> = 20 包年）独立相关： 224.89 mm，P = 0.05），空腹血糖高于7 mmol/L（-53.17 μm，P = 0.02），降脂治疗（+18.23，P = 0.047）。对年龄、性别、眼轴长度、血管和遗传危险因素进行多变量调整后，中央色素沉着过度（-45.39μm，P = 0.006）、中央色素减退（-44.99μm，P = 0.001）和中央色素异常（-44.50μm，P = 0.001）的眼睛的中心凹下脉络膜厚度较薄，但患有中央色素沉着的眼睛则不然。晚期年龄相关性黄斑变性（-18.05μm，P = 0.33）或软玻璃膜疣。结论：这些发现表明血管危险因素与脉络膜变薄之间存在关系，并表明脉络膜早期参与年龄相关性黄斑变性的发病机制。
Purpose: To study the associations of subfoveal choroidal thickness with vascular risk factors and age-related macular degeneration.Methods: Two hundred sixty-one participants of the Alienor study had gradable enhanced-depth imaging optical coherence tomography scans of the macula and available data on vascular and genetic risk factors (assessed through face-to-face interview and fasting blood samples) and age-related macular degeneration status (assessed from retinal photographs and optical coherence tomography). Subfoveal choroidal thickness was measured manually on one horizontal scan passing through the fovea.Results: In a multivariate mixed linear model, subfoveal choroidal thickness was independently associated with age greater than 80 years (-21.77 mu m, P = 0.02), axial length (-21.77 mu m, P < 0.0001), heavy smoking (>= 20 pack-years: 224.89 mm, P = 0.05), fasting blood glucose higher than 7 mmol/L (-53.17 mu m, P = 0.02), and lipid-lowering treatment (+18.23, P = 0.047). After multivariate adjustment for age, sex, axial length, and vascular and genetic risk factors, subfoveal choroidal thickness was thinner in eyes with central hyperpigmentation (-45.39 mu m, P = 0.006), central hypopigmentation (-44.99 mu m, P = 0.001), and central pigmentary abnormalities (-44.50 mu m, P = 0.001), but not in eyes with late agerelated macular degeneration (-18.05 mu m, P = 0.33) or soft drusen.Conclusion: These findings indicate a relationship between vascular risk factors and choroidal thinning and suggest an early involvement of the choroid in the pathogenesis of age-related macular degeneration.