Interpregnancy interval and birth defects
Interpregnancy interval and birth defects
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DOI：
10.1002/bdra.23420
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发表时间：
2015-11-01
影响因子：
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通讯作者：
Yang, Wei
中科院分区：
文献类型：
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作者：
Mburia-Mwalili, Adel;Yang, Wei
研究背景孕间期是包括出生缺陷在内的各种不良出生结局的危险因素。我们调查了interpregnancy间隔和出生缺陷之间的关系。MethodsWe进行了一项回顾性队列研究，使用关联数据从内华达州出生结局监测系统和出生证明数据为124,341单胎活产，其中4641名婴儿有7192出生缺陷，在2006年和2011年之间的内华达州居民妇女。我们使用Logistic回归评估因素独立与出生defects.ResultsWomen有一个interpregnancy间隔为36个月或以上，调整后的比值比（AOR）=1.16，95%的置信区间[CI]，1.01-1.33，更有可能有一个婴儿与出生缺陷相比，妇女interpregnancy间隔为18至23个月。出生缺陷的其他独立危险因素包括男婴，AOR=1.34，95%CI，1.26-1.42;母亲年龄，（30-34岁）和高龄产妇（35岁及以上），AOR=1.10，95% CI，1.01-1.19和AOR=1.29，95% CI，1.18-1.42;黑人女性，AOR=1.46，95% CI，1.32-1.61; 3次和4次及以上生育，AOR=1.12，95% CI，1.02-1.23和AOR=1.24，95% CI，1.11-1.38，吸烟，AOR=1.23，95% CI，1.10-1.38;与使用处方药有关，AOR=1.14，95% CI为1.07- 1.21。结论出生缺陷的独立危险因素是出生缺陷的间隔时间长。这可能有助于孕产妇和儿童健康计划和卫生保健提供者强调长时间解释间隔的有害影响。出生缺陷研究（A部分），2015年。(c)2015 Wiley Periodicals，Inc.出生缺陷研究（A部分）103：904-912，2015年。(c)2015 Wiley Periodicals，Inc.
BackgroundInterpregnancy interval is a risk factor for various adverse birth outcomes including birth defects. We investigated the relationship between interpregnancy interval and birth defects.MethodsWe conducted a retrospective cohort study using linked data from Nevada Birth Outcomes Monitoring System and birth certificate data for 124,341 singleton live births, of which 4641 infants had 7192 birth defects, among Nevada resident women between 2006 and 2011. We used logistic regression to assess factors independently associated with birth defects.ResultsWomen who had an interpregnancy interval of 36 months or more, adjusted odds ratio (AOR)=1.16, 95% confidence interval [CI], 1.01-1.33, were more likely to have an infant with a birth defect compared with women with an interpregnancy interval of 18 to 23 months. Other independent risk factors for birth defects included male infants, AOR=1.34, 95% CI, 1.26-1.42; maternal age (30-34 years) and advanced maternal age (35 years and older), AOR=1.10, 95% CI, 1.01-1.19 and AOR=1.29, 95% CI, 1.18-1.42, respectively; being a Black woman, AOR=1.46, 95% CI, 1.32-1.61; three and four or more previous births, AOR=1.12, 95% CI, 1.02-1.23 and AOR=1.24, 95% CI, 1.11-1.38, respectively; smoking, AOR=1.23, 95% CI, 1.10-1.38; and prescription drug use, AOR=1.14, 95% CI, 1.07-1.21.ConclusionA long interpregnancy interval is an independent risk factor for birth defects. It may be helpful for maternal and child health programs and health care providers to highlight the deleterious effects of a long interpregnancy interval. Birth Defects Research (Part A), 2015. (c) 2015 Wiley Periodicals, Inc. Birth Defects Research (Part A) 103:904-912, 2015. (c) 2015 Wiley Periodicals, Inc.