Fish consumption and breast cancer risk.: The European Prospective Investigation into Cancer and Nutrition (EPIC)
Fish consumption and breast cancer risk.: The European Prospective Investigation into Cancer and Nutrition (EPIC)
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DOI：
10.1002/ijc.21819
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发表时间：
2006-07-01
影响因子：
6.4
通讯作者：
Riboli, E
中科院分区：
文献类型：
--
作者：
Engeset, D;Alsaker, E;Riboli, E
目前人们对食用鱼类和海洋omega-3(n-3)脂肪酸与乳腺癌风险感兴趣。一些体外和动物研究表明，海洋n-3脂肪酸对乳腺癌生长有抑制作用，但研究食用鱼类与人类乳腺癌风险之间关系的流行病学研究的结果并不一致。我们调查了310,671名年龄在25岁到70岁之间的女性在加入欧洲癌症和营养前瞻性调查(EPIC)时的鱼类消费和乳腺癌风险。参与者在1992-98年间完成了一份饮食调查问卷，并对乳腺癌的发病率进行了中位数6.4年的跟踪调查。通过摄入总鱼、瘦鱼和富含脂肪的鱼来估计乳腺癌的风险比，并按研究中心进行分层，并根据确定的乳腺癌危险因素进行调整。在随访期间，报告了4776例浸润性乳腺癌。没有观察到总鱼类摄入量与乳腺癌风险之间的显著关联，危险比(HR)1.01(95%可信区间[CI]0.99-1.02；p=0.28每10克鱼/天)。当分别检查瘦鱼和粗壮的鱼时，我们只在脂肪鱼的最高五分之一(HR 1.13，95%CI 1.01-1.26)中找到了正相关，但趋势检验没有显著意义(p=0.10)。当研究参与者按绝经状态细分时，没有观察到与乳腺癌风险的相关性。尽管随访期相对较短，但研究结果并未提供鱼摄入量与乳腺癌风险之间存在关联的证据。(C)2006年Wiley-Liss，Inc.
There is current interest in fish consumption and marine omega-3 (n-3) fatty acids and breast cancer risk. Some in vitro and animal studies have suggested an inhibitory effect of marine n-3 fatty acids on breast cancer growth, but the results from epidemiological studies that have examined the association between fish consumption and breast cancer risk in humans are inconsistent. We examined fish consumption and breast cancer risk in 310,671 women aged between 25 and 70 yr at recruitment into the European Prospective Investigation Into Cancer and Nutrition (EPIC). The participants completed a dietary questionnaire between 1992-98 and were followed up for incidence of breast cancer for a median of 6.4 yr. Hazard ratio for breast cancer by intake of total and lean and fatty fish were estimated, stratified by study centre and adjusted for established breast cancer risk factors. During follow-up, 4,776 invasive incident breast cancers were reported. No significant associations between intake of total fish and breast cancer risk were observed, hazard ratio (HR) 1.01 (95% confidence interval [CI] 0.99-1.02; p = 0.28 per 10 g fish/day). When examining lean and ratty fish separately, we round a positive significant association only in the highest quintile for fatty fish (HR 1.13, 95% CI 1.01-1.26), but test for trend was not significant (p = 0.10). No associations with breast cancer risk were observed when the study participants were subdivided by menopausal status. Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk. (c) 2006 Wiley-Liss, Inc.