High cholesterol levels in patients with panic disorder.
High cholesterol levels in patients with panic disorder.
复制标题
恐慌症患者的胆固醇水平较高。
DOI：
10.1176/ajp.149.3.376
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
vanPraag,HM
中科院分区：
文献类型：
--
作者：
Bajwa,WK;Asnis,GM;Sanderson,WC;Irfan,A;vanPraag,HM
本研究的目的是为了帮助澄清在惊恐障碍患者中发现的较高的胆固醇水平是否是惊恐障碍的并发症或与任何精神disorder.MethodThe研究的对象是30例惊恐障碍患者和30例抑郁症患者，根据DSM-III-R的结构化访谈诊断，和30名正常对照组。这三组受试者的性别和年龄相匹配，没有一个受试者有酒精/药物滥用、异常ECG或不稳定的医疗状况。随机抽取血液样本，血清胆固醇水平determined.ResultsThe惊恐障碍患者有显着高于抑郁症患者和正常对照组的血清胆固醇水平。在重度抑郁症患者中，焦虑症病史（当前或过去）与血清胆固醇水平显著升高相关。稳定的医疗条件的存在是不相关的胆固醇水平较高的任何三组subjects.ConclusionsHigher胆固醇水平特别与恐慌症相比，与抑郁症。惊恐障碍中胆固醇水平升高被假设是去甲肾上腺素能活性增加的结果，这可能是惊恐障碍症状（包括预期焦虑）的潜在生物/神经化学机制。
ObjectiveThis study was undertaken to help clarify whether the higher cholesterol levels found in patients with panic disorder are a complication of panic disorder only or are associated with any psychiatric disorder.MethodThe subjects of the study were 30 patients with panic disorder and 30 patients with major depression, diagnosed according to the Structured Interview for DSM-III-R, and 30 normal control subjects. The three groups were matched for sex and age, and none of the subjects had alcohol/drug abuse, abnormal ECGs, or unstable medical conditions. Blood samples were drawn at random times, and serum cholesterol levels were determined.ResultsThe patients with panic disorder had significantly higher serum cholesterol levels than did the patients with major depression and the normal control subjects. Among the patients with major depression, histories (current or past) of anxiety disorders were associated with significant elevation of serum cholesterol levels. The presence of stable medical conditions was not associated with higher cholesterol levels in any of the three groups of subjects.ConclusionsHigher cholesterol levels were particularly associated with panic disorder in comparison with major depression. Higher levels of cholesterol in panic disorder are hypothesized to be a result of increased noradrenergic activity, which may be the underlying biological/neurochemical mechanism for symptoms of panic disorder, including anticipatory anxiety.