Information propagation in a noisy gene cascade.
Information propagation in a noisy gene cascade.
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DOI：
10.1103/physreve.96.012403
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
D. Monteoliva;Luis Diambra
中科院分区：
文献类型：
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作者：
D. Monteoliva;Luis Diambra
我们利用信息论来研究通过一个简单的基因级联的信息传递，其中一个不受管制的基因的产物调节一个合作基因开关的表达活性。而输入信号是由上游基因以两种状态提供的，我们认为下游基因的表达是由一个具有三个调节产物结合位点的顺式调控系统控制的，它们可以协同结合。通过精确计算关联概率分布，我们通过互信息测度来估计信息的传递。我们发现与单峰输入信号相关的互信息低于与双峰输入信号相关的互信息。我们还观察到互信息在协同性强度上呈现最大值，而这个最大值的位置取决于启动子的动力学速率。此外，我们发现输入信号的突发动态可以提高信息的传输能力。
We use information theory to study the information transmission through a simple gene cascade where the product of an unregulated gene regulates the expression activity of a cooperative genetic switch. While the input signal is provided by the upstream gene with two states, we consider that the expression of downstream gene is controlled by a cis-regulatory system with three binding sites for the regulator product, which can bind cooperatively. By computing exactly the associated probability distributions, we estimate information transmission thought the mutual information measure. We found that the mutual information associated with unimodal input signal is lower than the associated with bimodal inputs. We also observe that mutual information presents a maximum in the cooperativity intensity, and the position of this maximum depends on the kinetic rates of the promoter. Furthermore, we found that the bursting dynamics of the input signal can enhance the information transmission capacity.