Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia
Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia
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DOI：
10.1016/j.biopsych.2009.10.026
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发表时间：
2010-05-15
影响因子：
10.6
通讯作者：
McGuire, Philip K.
中科院分区：
文献类型：
--
作者：
Borgwardt, Stefan J.;Picchioni, Marco M.;McGuire, Philip K.
背景：灰质体积（GMV）的改变是精神分裂症的一个显著特征。然而，目前尚不清楚这些异常在多大程度上与疾病的遗传易感性相关，而不是环境因素和疾病本身。我们调查了遗传和环境风险对精神分裂症的同卵双生子（MZ）一致和不一致的GMV的影响。方法：从80对双胞胎的磁共振图像中测量了总的和局部的GMV：14对精神分裂症的MZ一致，9对精神分裂症的不一致，和17对健康的MZ双生子。精神分裂症双胞胎（t =-3.17，p = 0.003）和非精神病双胞胎（t =-2.66，p = 0.011）的总GMV小于健康对照双胞胎。精神分裂症患者的双胞胎在额下回、额内侧回、扣带回前部、尾状回、舌回和小脑的局部GMV较健康双胞胎降低（p <0.05，校正）。在不一致的配对中，精神分裂症双胞胎的GMV比非精神病双胞胎的GMV更少，在额叶、上级/内侧额叶、中央前/后、扣带回和上级颞回以及中央旁小叶。非精神病cotwin和健康对照subjects.Conclusions：精神分裂症的存在是特别相关的GMV减少额叶，岛叶，扣带回，内侧顶叶，颞叶皮层，超过和以上的遗传风险的影响障碍。这些变化可能与疾病本身的病理生理学或独特的环境因素有关。
Background: Alterations in gray matter volume (GMV) are a robust feature of schizophrenia. However, it is not clear to what extent these abnormalities are correlates of the genetic liability to the disorder, as opposed to environmental factors and the disorder itself. We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia.Methods: Total and regional GMVs were measured from magnetic resonance images of 80 twins: 14 MZ pairs concordant for schizophrenia, 9 pairs discordant for schizophrenia, and 17 healthy MZ twin pairs.Results: Total GMV was smaller in twins with schizophrenia (t = -3.17, p = .003) and nonpsychotic cotwins from discordant pairs (t = -2.66, p = .011) than in healthy control twins. Twin pairs concordant for schizophrenia displayed reduced regional GMV in the inferior frontal, medial frontal, and anterior cingulate gyri; the caudate; lingual gyrus; and cerebellum relative to healthy twins (p < .05, corrected). Within discordant pairs, twins with schizophrenia had less GMV than their nonpsychotic cotwins in the insula; superior/medial frontal, pre/postcentral, cingulate, and superior temporal gyri; and the paracentral lobule. There were no significant differences in regional GMV between nonpsychotic cotwins and healthy control subjects.Conclusions: The presence of schizophrenia was specifically related to reduced GMV in frontal, insular, cingulate, medial parietal, and temporal cortex, over and above effects of genetic risk for the disorder. These changes could be related to the pathophysiology of the disorder itself or to unique environmental factors acting etiologically or because of the illness.