Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
复制标题
响应凝血酶，从人血小板的磷脂中选择性释放阿奇多糖酸。
DOI：
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复制
发表时间：
1977
影响因子：
15.9
通讯作者：
M. Silver
中科院分区：
文献类型：
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作者：
T. Bills;J. Smith;M. Silver
花生四烯酸在人血小板脂肪酸中是独一无二的，因为它是前列腺素和凝血烷的前体。由于花生四烯酸的一些氧合产物对血小板功能有强有力的影响，因此了解其前体的代谢是很重要的。人类血小板具有将血浆中的花生四烯酸纳入磷脂的机制，并且在凝血酶的作用下，它们揭示了从血小板磷脂酰胆碱和磷脂酰肌醇中水解花生四烯酸的机制。本报告讨论这些机制的特殊性。目前的研究表明，人血小板含有磷脂酶A2活性，优先释放花生四烯酸。其中一种活性特别利用1-酰基-2-花生四烯酰基-磷脂酰胆碱。另一种利用血小板磷脂酰肌醇和/或磷脂酰丝氨酸，两者都富含花生四烯酸。
Arachidonic acid is unique amongst human platelet fatty acids in that it is the precursor of prostaglandins and thromboxanes. Since a number of these oxygenated products of arachidonic acid have potent effects on platelet function, an understanding of the metabolsim of their precursor is important. Human platelets have a mechanism for incorporating arachidonic acid from plasma into their phospholipids and, in response to thrombin, they reveal mechanisms for hydrolyzing this arachidonic acid from platelet phosphatidylcholine and phosphatidylinositol. This report deals with the specificity of these mechanisms. The present studies show that human platelets contain phospholipase A2 activities that preferentially release arachidonic acid. One of these activities specifically utilizes 1-acyl-2-arachidonyl-phosphatidyl-choline. Another utilizes platelet phosphatidylinositol and/or phosphatidylserine, both of which are highly enriched with arachidonic acid.