RECRUITMENT OF A TRANSCRIPTIONAL COREPRESSOR COMPLEX TO c-Myc BY MM-1, A c-Myc-BINDING PROTEIN*
RECRUITMENT OF A TRANSCRIPTIONAL COREPRESSOR COMPLEX TO c-Myc BY MM-1, A c-Myc-BINDING PROTEIN*
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发表时间：
2001
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通讯作者：
A. Satou;T. Taira;Sanae M. M. Iguchi-Ariga-Sanae-M.-M.-Iguchi-Ariga-1395935820;H. Ariga
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作者：
A. Satou;T. Taira;Sanae M. M. Iguchi-Ariga-Sanae-M.-M.-Iguchi-Ariga-1395935820;H. Ariga
原癌基因产物c-Myc在转录调控中起激活和阻遏作用，其反式激活途径既有来自N端的，也有来自C端的，与染色质重塑复合物相连的，而反式阻遏途径仅来自C端，通过Max和Mad募集组蛋白去乙酰化酶（HDAC）复合物。我们已经证实一种新的c-Myc结合蛋白MM-1抑制了c-Myc的E-box依赖性转录活性（Mori，K.，Maeda，Y.，Kitaura，H.，Taira，T.，Iguchi-Ariga，S. M. M.，和Ariga，H.（一九九八年）
The protooncogene product c-Myc plays a role in tran-scription regulation both for activation and repression.While transactivation pathways of c-Myc either from theN-proximal or the C-proximal region that is linked to thechromatin remodeling complex have been identified, atransrepression pathway had been identified only fromthe C-proximal region via Max and Mad that recruit thehistone deacetylase (HDAC) complex. We have reportedthat a novel c-Myc-binding protein, MM-1, repressed theE-box-dependent transcription activity of c-Myc (Mori,K., Maeda, Y., Kitaura, H., Taira, T., Iguchi-Ariga,S. M. M., and Ariga, H. (1998)