CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis
CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis
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DOI：
10.1016/j.febslet.2013.04.046
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发表时间：
2013-06-19
期刊：
影响因子：
3.5
通讯作者：
Hara, Takahiko
中科院分区：
文献类型：
--
作者：
Tanegashima, Kosuke;Suzuki, Kenji;Hara, Takahiko
CXCL 12-CXCR 4通路的激活对于造血干细胞、各种免疫细胞和恶性肿瘤细胞的迁移至关重要。在这里，我们发现另一种CXC趋化因子CXCL 14以高亲和力特异性结合CXCR 4，并抑制CXCL 12介导的人白血病衍生细胞系和CD 34（+）造血祖细胞的趋化性。因此，CXCL 14作为CXCL 12的天然抑制剂起作用。我们的观察表明，CXCL 14代表，沿着与CXCR 7，与CXCL 12-CXCR 4轴共同进化的分子，以调节发育，干细胞维护和免疫应答中的重要生理过程。(C)2013年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Activation of the CXCL12-CXCR4 pathway is crucial for the migration of hematopoietic stem cells, various immune cells, and malignant tumor cells. Here, we show that another CXC chemokine, CXCL14, specifically binds to CXCR4 with high affinity and inhibits the CXCL12-mediated chemotaxis of human leukemia-derived cell lines and CD34(+) hematopoietic progenitor cells. Thus, CXCL14 functions as a natural inhibitor of CXCL12. Our observations suggest that CXCL14 represents, along with CXCR7, molecules that co-evolved with the CXCL12-CXCR4 axis to modulate important physiological processes in development, stem cell maintenance, and immune responses.Structured summary of protein interactions:CXCR4 physically interacts with CXCL14 anti bait coimmunoprecipitation by (View interaction). (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.