Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization.
Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization.
复制标题
CGRP (8-37) 和 CGRP 受体脱敏抑制动脉周围神经刺激引起的肠系膜动脉床血管舒张。
DOI：
10.1016/0006-291x(90)92390-l
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发表时间：
1990
影响因子：
3.1
通讯作者：
Westfall,TC
中科院分区：
文献类型：
--
作者：
Han,SP;Naes,L;Westfall,TC
我们提供了第一个功能证据，表明降钙素基因相关肽（8-37）诱导直接血管收缩，并可逆地拮抗降钙素基因相关肽（CGRP）诱导的肠系膜动脉床血管舒张，表明CGRP（8-37）是血管CGRP受体的竞争性拮抗剂。CGRP（8-37）和CGRP受体脱敏均可抑制动脉周围神经刺激引起的血管舒张。这些结果进一步支持了动脉周围神经刺激诱导的肠系膜血管非肾上腺素能非胆碱能舒张是由内源性CGRP及其受体介导的。
We provide the first functional evidence that calcitonin gene-related peptide (8–37) induces a direct vasoconstriction and reversibly antagonizes vasodilation of the mesenteric arterial bed induced by calcitonin gene-related peptide (CGRP) suggesting that CGRP (8–37) is a competitive antagonist of vascular CGRP receptors. Vasodilation induced by periarterial nerve stimulation was inhibited both by CGRP (8–37) and by desensitization of CGRP receptors. These results further support the evidence that the periarterial nerve stimulation-induced nonadrenergic noncholinergic vasodilation of the mesenteric vasculature is mediated by endogenous CGRP and its receptors.