The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.
The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.
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生物标志物富集常染色体显性多囊肾病囊液的蛋白质组。
DOI：
10.1002/prca.200800163
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Witzmann,FrankA
中科院分区：
文献类型：
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作者：
Mason,StephenB;Lai,Xianyin;Bacallao,RobertL;Blazer-Yost,BonnieL;Gattone,VincentH;Wang,KevinC;Witzmann,FrankA
常染色体显性遗传性多囊肾病（ADPKD）的特征是患者肾脏中出现大量充满液体的囊肿。我们最近发表了我们对多囊肾囊肿液蛋白质组的描述。作为后续实验，我们假设蛋白结合亚组分由ADPKD的机制或诊断相关分子组成。使用手动生物标志物富集试剂盒，我们已经确定了44个不同的蛋白质在人类囊肿液。
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid‐filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow‐up experiment, we hypothesized that the protein‐bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.