COURTSHIP IN SACCHAROMYCES-CEREVISIAE - BOTH CELL-TYPES CHOOSE MATING PARTNERS BY RESPONDING TO THE STRONGEST PHEROMONE SIGNAL
COURTSHIP IN SACCHAROMYCES-CEREVISIAE - BOTH CELL-TYPES CHOOSE MATING PARTNERS BY RESPONDING TO THE STRONGEST PHEROMONE SIGNAL
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DOI：
10.1016/0092-8674(90)90507-b
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发表时间：
1990-11-30
期刊：
影响因子：
64.5
通讯作者：
HARTWELL, LH
中科院分区：
文献类型：
--
作者：
JACKSON, CL;HARTWELL, LH
我们证明，在求偶阶段的共轭，S。酿酒酵母A细胞选择α。从潜在的交配伙伴中产生最高水平的信息素的细胞。从这个结果和α.细胞，我们得出结论，α和α。细胞在求偶过程中充当信号细胞，这两种细胞类型通过区分不同水平的信号做出反应，并且这些信号是交配信息素。对信号超敏感的反应细胞无法区分信息素产生细胞和非产生细胞，这取决于它们的超敏感程度。我们建议，合作伙伴选择在S。酿酒酵母的这种梯度是由响应细胞在最高信息素浓度方向上的极化形态发生引起的，并且在区分这种梯度方面有缺陷的细胞执行随机选择相邻细胞的默认途径。
We demonstrate that during the courtship stage of conjugation, S. cerevisiae a cells choose the .alpha. cell producing the highest level of pheromone from among potential mating partners. From this result and that for .alpha. cells we conclude that both a and .alpha. cells act as signaling cells during courtship, that both cell types respond by discriminating different levels of signal, and that the signals are the mating pheromones. Responding cells that are supersensitive to signal fail to discriminate pheromone-producing from nonproducing cells to an extent that depends on their degree of supersensitivity. We propose that partner selection in S. cerevisiae results from polarized morphogenesis of a responding cell in the direction of highest pheromone concentration and that cells defective in discriminating this gradient execute a default pathway in which an adjacent cell is selected at random.