Comparison of methods for the rapid laboratory assessment of children with malaria
Comparison of methods for the rapid laboratory assessment of children with malaria
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DOI：
10.4269/ajtmh.2001.65.599
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Kremsner, PG
中科院分区：
文献类型：
--
作者：
Planche, T;Krishna, S;Kremsner, PG
恶性疟原虫寄生虫血症的快速诊断和准确定量对于疟疾的管理非常重要，疾病严重程度的评估还取决于血糖和乳酸浓度等代谢指标的评估。在这里，我们描述了一个准确和快速的替代传统的厚膜检查（兰巴丹法）。我们还评估了用于测量血糖（OneTouch）和乳酸（Accusport）的近患者方法。兰巴内方法的精度与薄膜的精度相似。OneTouch血糖仪的结果与YSI 2300参考血糖仪的结果也非常一致。总体而言，Accusport乳酸盐测定仪与YSI 2300参考测定仪的一致性较差。然而，检测高乳酸血症（血乳酸大于或等于5 mmol/L）的灵敏度和特异性分别为0.94和0.98。
Rapid diagnosis and accurate quantification of Plasmodium falciparum parasitemia are important for the management of malaria, The assessment of disease severity also depends on evaluation of metabolic indexes such as blood glucose and lactate concentrations. Here we describe an accurate and rapid alternative to conventional thick film examination (Lambardene method). We also assess near-patient methods for measuring blood glucose (OneTouch) and lactate (Accusport). The accuracy of the Lambarene method is similar to that of thin films. Results from the OneTouch glucose meter also are in good agreement with a YSI 2300 reference meter. Overall, the Accusport lactate meter agrees poorly with the YSI 2300 reference meter. However, the sensitivity and specificity to detect hyperlactatemia (blood lactate greater than or equal to 5 mmol/L) are 0.94 and 0.98, respectively.