Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.
Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.
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DOI：
10.1186/2045-5380-2-5
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发表时间：
2012-03-02
期刊：
影响因子：
--
通讯作者：
Holmes A
中科院分区：
文献类型：
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作者：
Kiselycznyk C;Hoffman DA;Holmes A
钾离子通道被认为在神经可塑性机制中发挥作用，Kv4.2亚基参与了动作电位向树突反向传播的调节。可塑性机制的改变已被进一步提出为各种精神疾病的基础，但Kv4.2在焦虑或抑郁中的作用还不清楚。在本文中，我们分析了表型Kv4.2基因敲除小鼠的神经功能的基础上，电池的行为，包括那些与焦虑和抑郁，以及可塑性相关的学习任务。我们在基因敲除小鼠中发现了一种新奇诱导的多动表型，这些小鼠也表现出对新奇刺激（如听觉音调）的反应性增加。没有观察到明确的焦虑或抑郁相关的表型，也没有任何改变学习/可塑性为基础的范例。我们没有发现明确的证据表明Kv4.2参与神经精神或可塑性相关的表型，但有支持Kv4.2在抑制对新刺激的兴奋性反应中的作用。
Potassium channels have been proposed to play a role in mechanisms of neural plasticity, and the Kv4.2 subunit has been implicated in the regulation of action-potential back-propagation to the dendrites. Alterations in mechanisms of plasticity have been further proposed to underlie various psychiatric disorders, but the role of Kv4.2 in anxiety or depression is not well understood. In this paper, we analyzed the phenotype Kv4.2 knockout mice based on their neurological function, on a battery of behaviors including those related to anxiety and depression, and on plasticity-related learning tasks. We found a novelty-induced hyperactive phenotype in knockout mice, and these mice also displayed increased reactivity to novel stimulus such as an auditory tone. No clear anxiety- or depression-related phenotype was observed, nor any alterations in learning/plasticity-based paradigms. We did not find clear evidence for an involvement of Kv4.2 in neuropsychiatric or plasticity-related phenotypes, but there was support for a role in Kv4.2 in dampening excitatory responses to novel stimuli.