ISOLATION OF HANTAAN VIRUS, THE ETIOLOGIC AGENT OF KOREAN HEMORRHAGIC-FEVER, FROM WILD URBAN RATS
ISOLATION OF HANTAAN VIRUS, THE ETIOLOGIC AGENT OF KOREAN HEMORRHAGIC-FEVER, FROM WILD URBAN RATS
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DOI：
10.1093/infdis/146.5.638
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
JOHNSON, KM
中科院分区：
文献类型：
--
作者：
LEE, HW;BAEK, LJ;JOHNSON, KM
在首尔和附近的4个韩国城市捕获的城市老鼠具有与韩国出血热(KHF)的病原体汉滩病毒(Hantaan Virus)反应的免疫荧光抗体。477只褐家鼠血清抗体阳性率为13%，47只褐家鼠血清抗体阳性率为11%。在42只动物的肺组织中发现了汉滩病毒抗原，从23只大鼠中发现了汉滩病毒，除2只外，其余均为褐家鼠。从野鼠组织中分离病毒，Wistar大鼠比黑线姬鼠敏感得多。用这些毒株中的1株免疫Wistar大鼠，至少75天后在肺和脾内出现病毒。这些结果证明了汉滩病毒存在一个城市循环，这是根据KHF人群中发生的散发性城市病例而被怀疑的，并表明汉滩病毒可能在城市中心广泛分布。
Urban rats captured in Seoul and 4 nearby Korean cites had immunofluorescent antibodies reactive with Hantaan virus, the etiologic agent of Korean hemorrhagic fever (KHF). Serum antibodies were detected in 13% of 477 Rattus norvegicus and 11% of 47 R. rattus. Hantaan viral antigen was found in pulmonary tissues of 42 animals and Hantaan virus was recovered from 23 rats, all but 2 of which were R. norvegicus. Wistar rats were qualitatively much more sensitive than Apodemus agrarius rodents for isolation of virus from tissues of wild rats. Wistar rats inoculated with 1 of these strains had virus in lung and spleen for at least 75 days. These results document the existence of an urban cycle for Hantaan virus, which had been suspected on the basis of the occurrence of sporadic urban cases in humans of KHF, and suggest that Rattus-borne Hantaan virus may be widely distributed in urban centers.