Quantitative Analysis of Vertebral Bone Marrow Perfusion Using Dynamic Contrast-Enhanced MRI: Initial Results in Osteoporotic Patients With Acute Vertebral Fracture
Quantitative Analysis of Vertebral Bone Marrow Perfusion Using Dynamic Contrast-Enhanced MRI: Initial Results in Osteoporotic Patients With Acute Vertebral Fracture
复制标题
DOI：
10.1002/jmri.22497
复制
发表时间：
2011-03-01
影响因子：
4.4
通讯作者：
Baur-Melnyk, Andrea
中科院分区：
文献类型：
--
作者：
Biffar, Andreas;Schmidt, Gerwin P.;Baur-Melnyk, Andrea
目的：目的探讨动态增强MRI（DCE-MRI）在急性椎体压缩骨折患者椎体骨髓（vBM）定量分析中的应用价值。材料与方法：26例急性骨质疏松性骨折患者（16例女性，10例男性，中位年龄72岁，范围48-89）和10例无已知骨质疏松症病史的受试者（6名女性，4名男性，中位数65，范围3177）进行了2D-DCE-MRI检查。用二室示踪剂动力学模型分析骨折（n = 26）和正常椎骨（n = 271）的感兴趣区域（ROI）数据，提供至少三个独立参数的估计值：血浆流量（PF）、血浆体积（PV）和提取流量（EF）。参数与双能X线吸收法（DXA）（n = 15）和定量计算机断层扫描（QCT）密度测定（n = 10）。结果：骨折的平均PF显著高于正常椎骨（69.37 vs. 11.72 mL/100 mL/min）。同样，平均PV和EF也存在显著差异。与对照组相比，正常vBM肺水肿患者的平均PF显著降低。与胸椎相比，腰椎的平均PF和PV显著降低。结论：正常vBM患者的灌注参数明显降低。此外，与正常椎骨相比，在急性骨质疏松性椎骨骨折中观察到显著的灌注改变。
Purpose: To evaluate the potential of quantitative dynamic contrast-enhanced MRI (DCE-MRI) in vertebral bone marrow (vBM) of patients with acute osteoporotic vertebral compression fractures.Materials and Methods: Twenty-six patients with acute osteoporotic fractures (16 female, 10 male, median age 72, range 48-89) and 10 subjects without known history of osteoporosis (6 female, 4 male, median 65, range 3177) were examined 2D-DCE-MRI. Region of interest (ROI) data in fractured (n = 26) and normal-appearing vertebrae (n = 271) were analyzed with a two-compartment tracer-kinetic-model, providing estimates of at least three independent parameters: plasma flow (PF), plasma volume (PV), and extraction flow (EF). Parameters were correlated with dual x-ray absorptiometry (DXA) (n = 15) and quantitative computed tomography (QCT) densitometry (n = 10).Results: Mean PF was significantly higher in fractures than in normal-appearing vertebrae (69.37 vs. 11.72 mL/100 mL/min). Similarly, mean PV and EF differed significantly. Mean PF was significantly decreased in normal-appearing vBM osteoporotic patients compared to the control group. Mean PF and PV were significantly decreased in lumbar compared to thoracic vertebrae. PV showed a significant correlation with QCT.Conclusion: Perfusion parameters were decreased significantly in normal-appearing vBM of patients. Furthermore, significant perfusion alterations were observed in acute osteoporotic vertebral fractures compared to normal-appearing vertebrae.