COMPARISON OF THE INITIAL STREPTOCOCCAL MICROFLORA ON DENTAL ENAMEL IN CARIES-ACTIVE AND IN CARIES-INACTIVE INDIVIDUALS
COMPARISON OF THE INITIAL STREPTOCOCCAL MICROFLORA ON DENTAL ENAMEL IN CARIES-ACTIVE AND IN CARIES-INACTIVE INDIVIDUALS
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DOI：
10.1159/000261281
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发表时间：
1990-07-01
期刊：
影响因子：
4.2
通讯作者：
KILIAN, M
中科院分区：
文献类型：
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作者：
NYVAD, B;KILIAN, M
这项研究比较了 7 名龋齿活跃青少年和 7 名龋齿非活跃青少年牙釉质上的初始（4 小时）微生物群落。在两组中，微生物区系均以链球菌为主，链球菌分别占龋齿活跃和龋齿非活跃个体总活菌数的 61% 和 78%（中值）（p < 0.01）。根据最近修订的分类，对总共 700 个链球菌分离株的鉴定表明，主要链球菌属于口链球菌、S. mitis biovar 1 和 S. sanguis 种。非龋齿活跃个体的早期牙菌斑与龋齿活跃个体的不同之处在于，血链球菌 (p < 0.05) 和产生 IgA1 蛋白酶的链球菌 (p < 0.05) 的比例显着更高。在龋齿活跃的个体中，S. mitis biovar 1 的水平有升高的趋势 (p < 0.10)。此外，龋齿活跃个体牙釉质表面上的变形链球菌数量显着增加（p < 0.01）。然而，在两组中，变形链球菌（血清型c）占早期链球菌菌群的≤2%。 S. gordonii、S. mitis biovar 2 和 S. salivarius 的比例较低，并且没有显示出可能与龋齿活动相关的分布差异。观察到的早期链球菌微生物群组成的差异可能是控制牙菌斑最终致龋可能性的一个因素。
This study compared the initial (4 h) microflora on enamel in 7 caries-active and in 7 caries-inactive adolescents. In both groups the microflora was dominated by streptococci which comprised 61 and 78% (median values) of the total viable counts in caries-active and caries-inactive individuals, respectively (p < 0.01). Identification of a total of 700 streptococcal isolates according to a recently revised classification showed that the predominant streptococci belonged to the species Streptococcus oralis, S. mitis biovar 1, and S. sanguis. Early plaque from caries-inactive individuals differed from that of caries-active individuals by significantly higher proportions of S. sanguis (p < 0.05) and IgA1 protease producing streptococci (p < 0.05). In caries-active individuals, there was a tendency to elevated levels of S. mitis biovar 1 (p < 0.10). In addition, caries-active individuals were colonized by significantly higher numbers of mutans streptococci on the enamel surfaces (p < 0.01). However, in both groups S. mutans (serotype c) comprised .ltoreq.2% of the early streptococcal flora. S. gordonii, S. mitis biovar 2, and S. salivarius were present in low proportions and did not show differences in distribution that could be related to caries activity. The observed differences in the composition of the early streptococcal microflora may be a factor that governs the eventual cariogenic potential of dental plaque.