Antioxidant properties of ferulic acid and its related compounds
Antioxidant properties of ferulic acid and its related compounds
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DOI：
10.1021/jf011348w
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发表时间：
2002-03-27
影响因子：
6.1
通讯作者：
Taniguchi, H
中科院分区：
文献类型：
--
作者：
Kikuzaki, H;Hisamoto, M;Taniguchi, H
用几种不同的物理系统对24种阿魏酸相关化合物和6种没食子酸相关化合物的抗氧化活性及自由基清除活性进行了评价。对1,1-二苯基-2-苦基肼基（DPPH）自由基清除能力的强弱顺序为咖啡酸b>辛酸b>阿魏酸b>阿魏酸酯b>对香豆酸。在散装亚油酸甲酯中，羟基肉桂酸和阿魏酸酯的抗氧化活性与自由基清除活性相当。在亚油酸乙醇缓冲溶液中，测试化合物的活性并不总是与其自由基清除活性相关。阿魏酸是最有效的酚酸。阿魏酸的酯化反应使活性增加。阿魏酸烷基酯的活性受醇段链长影响较大。阿魏酸烷基对AAPH诱导的脂质体氧化的抑制作用表明，阿魏酸己基、辛基和2-乙基-1-己基阿魏酸酯比其他阿魏酸烷基活性更强。其中，没食子酸十二酯的效果最好。这些结果表明，抗氧化剂的自由基清除能力及其与脂质底物的亲和力可能是影响其活性的重要因素。
Antioxidant activity of 24 ferulic acid related compounds together with 6 gallic acid related compounds was evaluated using several different physical systems as well as their radical scavenging activity. The radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) decreased in the order caffeic acid > sinapic acid > ferulic acid > ferulic acid esters > p-coumaric acid. In bulk methyl linoleate, test hydroxycinnamic acids and ferulic acid esters showed antioxidant activity in parallel with their radical scavenging activity. In an ethanol-buffer solution of linoleic acid, the activity of test compounds was not always associated with their radical scavenging activity. Ferulic acid was most effective among the tested phenolic acids. Esterification of ferulic acid resulted in increasing activity. The activity of alkyl ferulates was somewhat influenced by the chain length of alcohol moiety. When the inhibitory effects of alkyl ferulates against oxidation of liposome induced by AAPH were tested, hexyl, octyl, and 2-ethyl-1-hexyl ferulates were more active than the other alkyl ferulates. Furthermore, lauryl gallate is most effective among the tested alkyl gallates. These results indicated that not only the radical scavenging activity of antioxidants, but also their affinity with lipid substrates, might be important factors in their activity.