Respiratory quotient is inversely associated with muscle sympathetic nerve activity
Respiratory quotient is inversely associated with muscle sympathetic nerve activity
复制标题
DOI：
10.1210/jc.83.11.3977
复制
发表时间：
1998-11-01
影响因子：
5.8
通讯作者：
Ravussin, E
中科院分区：
文献类型：
--
作者：
Snitker, S;Tataranni, PA;Ravussin, E
个体被氧化的常量营养素的相对数量反映在呼吸商(RQ)中，呼吸商与脂质氧化成反比。高RQ表明相对较低的脂质氧化，以及交感神经系统的低活动都被认为是体重增加的危险因素。去甲肾上腺素对脂质氧化的刺激作用提示低脂氧化可能参与了交感神经活动减少与体重增加的关系。本研究的目的是确定低基础肌交感神经活动(MSNA)是否与低脂氧化独立相关，MSNA是交感神经流出的直接测量指标。39名健康的非糖尿病男性，19名高加索人(平均+/-SD，33+/-9岁，91+/-23公斤，28+/-11%体脂)和20名PIMA印第安人(30+/-5岁，94+/-25公斤，35+/-8%脂肪)在呼吸室测量24小时RQ后立即进行基础MSNA的神经内记录。基础MSNA、能量平衡和年龄是24小时RQ的独立决定因素，共同解释了其45%的变异性。相应地，经能量平衡和年龄调整后的24小时RQ与MSNA呈负相关(r=-0.41；P=0.01)。种族、体脂百分比和空腹血浆胰岛素不是24小时RQ的独立决定因素。尽管MSNA只解释了24小时RQ的有限部分变异性，但结果支持这样一种假设，即对脂质氧化的影响有助于证明交感神经系统的低活动与体重增加之间的关系。
The relative amounts of the macronutrients oxidized by an individual are reflected in the respiratory quotient (RQ), which varies inversely with lipid oxidation. A high RQ, indicating a relatively low lipid oxidation, and a low activity of the sympathetic nervous system have both been identified as risk factors for body weight gain. The stimulatory effect of norepinephrine on lipid oxidation suggests that low lipid oxidation may contribute to the relationship between low sympathetic nervous activity and body weight gain. The purpose of the present study was to determine whether low basal muscle sympathetic nerve activity (MSNA), a direct measure of sympathetic nervous outflow, is independently associated with low lipid oxidation. Intraneural recordings of basal MSNA were performed in 39 healthy, nondiabetic males, 19 Caucasians (mean +/-SD, 33 +/- 9 yr,91 +/- 23 kg, and 28 +/- 11% body fat) and 20 Pima Indians (30 +/- 5 yr, 94 +/- 25 kg, and 35 +/- 8% fat) immediately after measurement of 24-h RQ in a respiratory chamber. Basal MSNA, energy balance, and age were independent determinants of 24-h RQ, together explaining 45% of its variability. Accordingly, 24-h RQ adjusted for energy balance and age was inversely related to MSNA (r = -0.41; P = 0.01). Race, percent body fat, and fasting plasma insulin were not independent determinants of 24-h RQ. Although MSNA explained only a limited part of the variability in 24-h RQ, the results support the hypothesis that an effect on lipid oxidation contributes to the demonstrated relationship between low activity of the sympathetic nervous system and body weight gain.