Extracorporeal liver assist in the treatment of fulminant hepatic failure.
Extracorporeal liver assist in the treatment of fulminant hepatic failure.
复制标题
体外肝脏有助于治疗暴发性肝衰竭。
DOI：
10.1159/000170114
复制
发表时间：
1993
影响因子：
3
通讯作者：
Kelly,JH
中科院分区：
文献类型：
--
作者：
Sussman,NL;Kelly,JH
我们开发肝脏辅助设备的目标是提供肝脏支持并改善患者的代谢状态，以便原生肝脏有机会再生。如果做不到这一点，患者至少应该保持良好的健康状况，以便安全地进行肝移植。我们不知道维持生命需要多少代谢支持，但我们设定的目标是正常肝细胞质量的20%。我们的初步结果表明，这是一个适当的数字，一项确定安全性和有效性的临床试验正在德克萨斯州医学中心进行。
Our goal in developing a liver assist device is to provide liver support and improve the metabolic state of the patient so that the native liver has the opportunity to regenerate. Failing this, the patient should at least remain in satisfactory health so that liver transplantation can be performed safely. We have no idea how much metabolic support will be required to sustain life, but we have set a goal of 20% of the normal hepatocyte mass. Our initial results suggest that this is an appropriate number, and a clinical trial to determine safety and efficacy is under way at the Texas Medical Center.