Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides
Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides
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DOI：
10.1089/cbr.2005.20.436
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Volkert, WA
中科院分区：
文献类型：
--
作者：
Miller, WH;Hartmann-Siantar, C;Volkert, WA
几种短寿命的高能β发射体被提议作为分子靶向潜在癌症治疗剂的放射性核素成分。用于确定这些新药剂功效的实验室小鼠的器官与这些高能粒子的射程相比相对较小。 Hui 等人开发的剂量测定模型。扩展为接受含有 Y-90、Re-188、Ho-166、Pm-149、Cu-64 和 Lu-177 的治疗性放射性药物的小鼠器官提供真实的 β 剂量估计。该模型中的主要器官包括肝脏、脾脏、肾脏、肺、心脏、胃、小肠和大肠、甲状腺、胰腺、骨骼、骨髓、尸体和一个 0.025 克的肿瘤。本文报道的研究验证了他们对 Y-90 的结果，并通过使用其器官几何因素以及新计算的 PEREGRINE 和 MCNP 器官自吸收分数来扩展这些结果。 PEREGRINE 和 MCNP 同意最坏情况器官的误差在 8% 以内，平均差异（所有器官的平均值）从 Y-90 的 5% 降至 Lu-177 的 1%。当与典型的生物分布数据一起使用时，三种不同的模型预测的最坏情况器官的剂量一致在 5% 以内。本文提供的 β 吸收分数和跨器官沉积能量可被研究人员用来预测小鼠器官剂量，并有助于更好地理解小鼠模型中剂量与辐射毒性之间的关系，在这些模型中使用这些同位素是有利的。
Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular-targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing Y-90, Re-188, Ho-166, Pm-149, Cu-64, and Lu-177. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for Y-90 and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case organ with average differences (averaged over all organs) decreasing from 5% for Y-90 to 1% for Lu-177. When used with typical biodistribution data, the three different models predict doses that are in agreement to within 5% for the worst-case organ. The beta-absorbed fractions and cross-organ-deposited energy provided in this paper can be used by researchers to predict mouse-organ doses and should contribute to an improved understanding of the relationship between dose and radiation toxicity in mouse models where use of these isotopes is favorable.