Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease
Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease
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DOI：
10.1016/s0197-4580(97)00001-8
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发表时间：
1997-03-01
影响因子：
4.2
通讯作者：
George, A
中科院分区：
文献类型：
--
作者：
Convit, A;DeLeon, MJ;George, A
我们的目标是通过使用MRI衍生的体积来确定阿尔茨海默型痴呆(DAT)的临床前(尚不能诊断)阶段中颞叶的参与。我们评估了三组仔细筛选的年龄和教育程度匹配的老年人的颞叶解剖分区：27名正常老年人(NL)，22名轻度认知损伤(MCI)患者，他们不符合DAT标准，但被认为是未来DAT的高危人群，以及27名DAT患者。我们发现，与NL组相比，MCI组和DAT组的海马体体积分别减少了14%和22%。利用回归分析，在考虑了性别、头部大小、年龄、广泛性萎缩(CSF)和其他颞叶亚体积后，海马体体积将NL与MCI个体区分开来，正确分类为74%。对于NL组和MCI组，海马体积是唯一与延迟回忆记忆成绩相关的颞叶亚体积。当对比MCI和DAT个体时，梭形回体积独特地提高了海马体积区分MCI和DAT个体的能力，从74%到80%。我们的横断面数据表明，在颞叶内，特定的海马体体积减少将DAT风险组与正常组区分开来。随着时间的推移，损害足以做出DAT的诊断，除了内侧颞叶体积减少外，外侧颞叶也表现出体积减少，最明显的是梭形回。(C)1997年爱思唯尔科学公司。
Our goal was to ascertain the involvement of the temporal lobe in the preclinical (not yet diagnosable) stages of dementia of the Alzheimer's type (DAT) by using MRI-derived volumes. We assessed anatomical subdivisions of the temporal lobe on three groups of carefully screened age- and education-matched elderly individuals: 27 normal elderly (NL), 22 individuals with minimal cognitive impairment (MCI), who did not fulfill DAT criteria but were regarded at high risk for future DAT, and 27 DAT individuals. We found hippocampal volume reductions of 14% for the MCI and 22% for the DAT group compared to the NL group. Utilizing regression analyses and after accounting for gender, head size, age, generalized atrophy (CSF), and other temporal lobe subvolumes, the hippocampal volume separated NL from MCI individuals, correctly classifying 74%. For NL and MCI groups combined the hippocampal volume was the only temporal lobe subvolume related to delayed recall memory performance. When contrasting MCI and DAT individuals, the fusiform gyrus volume uniquely improved the ability of the hippocampal volume to separate MCI from DAT individuals from 74 to 80%. Our cross-sectional data suggest that, within the temporal lobe, specific hippocampal volume reductions separated the group at risk for DAT from the normal group. By the time impairments are sufficient to allow a diagnosis of DAT to be made, in addition to the medial temporal lobe volume reductions, the lateral temporal lobe is also showing volume reductions, most saliently involving the fusiform gyrus. (C) 1997 Elsevier Science Inc.