Neuropeptide abnormalities in patients with early Alzheimer disease
Neuropeptide abnormalities in patients with early Alzheimer disease
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DOI：
10.1001/archpsyc.56.11.981
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发表时间：
1999-11-01
影响因子：
--
通讯作者：
Haroutunian, V
中科院分区：
文献类型：
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作者：
Davis, KL;Mohs, RC;Haroutunian, V
背景资料：生长抑素样免疫反应性（SLI）和促肾上腺皮质激素释放因子免疫反应性（CRF-IR）的缺陷被公认为阿尔茨海默病（AD）中突出的神经化学缺陷。在终末期疾病患者中发现的这些严重的神经肽能缺陷是否延伸到那些早期疾病患者的问题相对没有答案。为了确定SLI和CRF-IR水平之间的关系，在不同的大脑皮层区域的认知功能恶化的最早迹象AD。方法：我们研究了SLI和CRF-IR水平在9个新皮层脑区的66名老年患者在尸检研究的养老院居民没有显着的神经病理学病变或病变只与AD。患者通过临床痴呆评定量表（CDR）评估为无痴呆或可疑、轻度或中度痴呆，并与15例重度痴呆患者进行比较。在最严重痴呆患者的皮质中，CRF-IR和SLI均显著降低，而轻度（CDR = 1.0）和中度（CDR = 2.0）痴呆患者CRF-IR水平降低。CRF-IR和SLI的水平与CDR显着相关，但这种相关性是更强大的CRF-IR和持久的，即使当严重的认知功能障碍的患者被淘汰的analysis.Conclusions：虽然SLI和CRF-TR水平显着降低，在重度痴呆患者，只有CRF-IR显着降低，在那些轻度痴呆的皮质。因此，CRF-IR可以作为早期痴呆和可能的早期AD的潜在神经化学标志物。
Background: Deficits in somatostatin-like immunoreactivity (SLI) and corticotropin-releasing factorimmunoreactivity (CRF-IR) are well recognized as prominent neurochemical deficits in Alzheimer disease (AD). The question of whether these profound neuropeptidergic deficits found in patients with end-stage disease extend into those with much earlier disease is relatively unanswered. To determine the relation between level of SLI and CRF-IR in different cerebrocortical regions to the earliest signs of cognitive deterioration in AD.Methods: We examined SLI and CRF-IR levels in 9 neocortical brain regions of 66 elderly patients in a postmortem study of nursing home residents who had either no significant neuropathologic lesions or lesions associated only with AD. Patients were assessed by the Clinical Dementia Rating scale (CDR) to have no dementia or questionable, mild, or moderate dementia, and were compared with 15 patients with severe dementia.Results: Both CRF-IR and SLI were significantly reduced in the cortices of patients with the most severe dementia, but only the levels of CRF-IR were reduced in those with mild (CDR = 1.0) and moderate dementia (CDR = 2.0). Levels of CRF-IR and SLI correlated significantly with CDR, but this correlation was more robust for CRF-IR and persisted even when severely cognitively impaired patients were eliminated from analysis.Conclusions: Although SLI and CRF-TR levels are significantly reduced in patients with severe dementia, only CRF-IR is reduced significantly in the cortices of those with mild dementia. Thus, CRF-IR can serve as a potential neurochemical marker of early dementia and possibly early AD.