Heart rate variability as a potential indicator of positive valence system disturbance: A proof of concept investigation
Heart rate variability as a potential indicator of positive valence system disturbance: A proof of concept investigation
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DOI：
10.1016/j.ijpsycho.2015.08.005
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发表时间：
2015-11-01
影响因子：
3
通讯作者：
Murray, Greg
中科院分区：
文献类型：
--
作者：
Gruber, June;Mennin, Douglas S.;Murray, Greg
更好地理解积极情绪障碍的病理生理学的一个有希望的途径是检查高频心率变异性（HRV-HF），它被认为是积极情绪功能障碍的潜在生理指标。迄今为止，只有少数精神病理学相关研究在日常生活中使用更生态有效的方法系统地量化了 HRV-HF 特征。本研究采用经验抽样方法，检查了日常生活中 HRV-HF 的平均水平和个体内变异性，以及心血管唤醒、交感神经活动和总体躯体运动的比较测量，在一系列具有不同程度正价系统紊乱的社区成人参与者中使用连续六天的动态心理生理学测量，包括患有双相情感障碍（BD；n = 21）、重度抑郁症（MDD；n = 17) 和健康的非精神病对照 (CTL; n = 28)。各组的平均 HRV-HF 没有差异，但与 MDD 组和 CTL 组相比，BD 组的 HRV-HF 不稳定性（即 HRV-HF 的个体内变异）更大。随后的分析表明，HRV-HF 变异性的群体差异很大程度上是由临床医生评定的躁狂症状的差异造成的。然而，HRV-HF 变异性与积极情感的维度测量之间没有发现关联。这项工作提供了与 HRV-HF 和正性情绪障碍之间的二次关系一致的证据，并且代表了在 RDoC 框架内开发更生态有效的正价系统障碍模型及其潜在心理生理机制的宝贵一步。 (C) 2015 年由 Elsevier B.V. 出版
One promising avenue toward a better understanding of the pathophysiology of positive emotional disturbances is to examine high-frequency heart rate variability (HRV-HF), which has been implicated as a potential physiological index of disturbances in positive emotional functioning. To date, only a few psychopathology relevant studies have systematically quantified HRV-HF profiles using more ecologically valid methods in everyday life. Using an experience-sampling approach, the present study examined both mean levels and intra-individual variability of HRV-HF - as well as comparison measures of cardiovascular arousal, sympathetic activity, and gross somatic movement - in everyday life, using ambulatory psychophysiological measurement across a six-day consecutive period among a spectrum of community adult participants with varying degrees of positive valence system disturbance, including adults with bipolar I disorder (BD; n = 21), major depressive disorder (MDD; n = 17), and healthy non-psychiatric controls (CTL; n = 28). Groups did not differ in mean HRV-HF, but greater HRV-HF instability (i.e., intra-individual variation in HRV-HF) was found in the BD compared to both MDD and CTL groups. Subsequent analyses suggested that group differences in HRV-HF variability were largely accounted for by variations in clinician-rated manic symptoms. However, no association was found between HRV-HF variability and dimensional measures of positive affectivity. This work provides evidence consistent with a quadratic relationship between HRV-HF and positive emotional disturbance and represents a valuable step toward developing a more ecologically valid model of positive valence system disturbances and their underlying psychophysiological mechanisms within an RDoC framework. (C) 2015 Published by Elsevier B.V.